Dihydrofolic acid
This article needs additional citations for verification. (October 2014) |
Names | |
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IUPAC name
N-(4-{[(2-amino-4-oxo-1,4,7,8-tetrahydropteridin-6-yl)methyl]amino}benzoyl)-L-glutamic acid
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Other names
H2folate, DH
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Identifiers | |
3D model (
JSmol ) |
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ChEBI | |
ChEMBL | |
ChemSpider | |
ECHA InfoCard
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100.116.435 |
MeSH | dihydrofolate |
PubChem CID
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UNII | |
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Properties | |
C19H21N7O6 | |
Molar mass | 443.414 g/mol |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Dihydrofolic acid (conjugate base dihydrofolate) (DHF) is a
pyrimidines, which are building blocks of DNA and RNA, dihydrofolate reductase is targeted by various drugs to prevent nucleic acid
synthesis.
Interactive pathway map
Click on genes, proteins and metabolites below to link to respective articles.[§ 1]
- ^ The interactive pathway map can be edited at WikiPathways: "FluoropyrimidineActivity_WP1601".
Further reading
- Gangjee, Aleem; Jain, Hiteshkumar D.; Kurup, Sonali (2007). "Recent Advances in Classical and Non-Classical Antifolates as Antitumor and Antiopportunistic Infection Agents: Part I". Anti-Cancer Agents in Medicinal Chemistry. 7 (5): 524–542. PMID 17896913.
References
- PMID 2372539.