Dilazep

Source: Wikipedia, the free encyclopedia.
Dilazep
Clinical data
Trade namesComelian Kowa
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 3-(4-{3-[(3,4,5-Trimethoxyphenyl)carbonyloxy]propyl}-1,4-diazepan-1-yl)propyl 3,4,5-trimethoxybenzoate
JSmol)
  • O=C(OCCCN2CCCN(CCCOC(=O)c1cc(OC)c(OC)c(OC)c1)CC2)c3cc(OC)c(OC)c(OC)c3
  • InChI=1S/C31H44N2O10/c1-36-24-18-22(19-25(37-2)28(24)40-5)30(34)42-16-8-12-32-10-7-11-33(15-14-32)13-9-17-43-31(35)23-20-26(38-3)29(41-6)27(21-23)39-4/h18-21H,7-17H2,1-6H3 checkY
  • Key:QVZCXCJXTMIDME-UHFFFAOYSA-N checkY
  (verify)

Dilazep is a

vasodilator that acts as an adenosine reuptake inhibitor.[1][2]

It is used for the treatment of

Synthesis

Thieme Patent:[4] Prec (page 935):[5]

The reaction of bis-(3-hydroxypropyl)-ethylene diamine (1) with 1-Bromo-3-chloropropane (2) gives homopiperazine [19970-80-0] (3). Esterification by reaction with 3,4,5-Trimethoxybenzoyl Chloride [4521-61-3] (4) completed the synthesis of Dilazep (5).

See also

References

  1. PMID 9310485
    .
  2. ^ PubChem. "Dilazep". pubchem.ncbi.nlm.nih.gov. Retrieved 2021-08-18.
  3. ^ "Pharmaceuticals". Kowa Company Ltd.
  4. ^ GB1107470 idem Herbert Arnold, Kurt Pahls, Rolf Rebling,Norbert Brock, Hans-Dieter Lenke, U.S. patent 3,532,685 (1970 to Asta Werke Ag Chem Fab).
  5. .