Dipeptidyl peptidase-4
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Location (UCSC) | Chr 2: 161.99 – 162.07 Mb | Chr 2: 62.16 – 62.24 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Dipeptidyl peptidase-4 (DPP4 or DPPIV), also known as adenosine deaminase complexing protein 2 or CD26 (
and as a result of various studies on chemism, was called dipeptidyl peptidase IV [DP IV].Function
The protein encoded by the DPP4 gene is an
DPP-4 is known to cleave a broad range of
DPP4 plays a major role in
DPP-4 also binds the enzyme adenosine deaminase specifically and with high affinity. The significance of this interaction has yet to be established.
Animal studies
Animal studies suggest its pathogenetic role in development of fibrosis of various organs, such as liver and kidney.[15][16]
Clinical significance
CD26/DPPIV plays an important role in tumor biology, and is useful as a marker for various cancers, with its levels either on the cell surface or in the serum increased in some neoplasms and decreased in others.[17]
A class of
DPP4,[20] or its Mycobacterial homologue MtDPP,[21] might play a role in the pathogenesis of tuberculosis via cleavage of the chemokine C-X-C motif chemokine ligand 10 (CXCL10).
See also
- Development of dipeptidyl peptidase-4 inhibitors
- Berberine
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000197635 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000035000 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8101391.
- S2CID 9674831.
- S2CID 37551773.
- ^ S2CID 22354304.
- PMID 16700505.
- S2CID 2645092.
- PMID 15375776.
- S2CID 2857735.
- PMID 15735018.
- PMID 14687920.
- S2CID 2726091.
- S2CID 23745972.
- PMID 17981655.
- S2CID 25482131.
- PMID 23486063.
- Tina Hesman Saey (March 13, 2013). "News in Brief: New virus uses protein handle to infect cells". ScienceNews. Archived from the original on 2013-03-20.
- PMID 30026741.
- S2CID 255596512.
Further reading
- Ansorge S, Bühling F, Kähne T, Lendeckel U, Reinhold D, Täger M, Wrenger S (1997). "CD26/Dipeptidyl Peptidase IV in Lymphocyte Growth Regulation". Cellular Peptidases in Immune Functions and Diseases. Advances in Experimental Medicine and Biology. Vol. 421. pp. 127–40. PMID 9330689.
- Reinhold D, Kähne T, Steinbrecher A, Wrenger S, Neubert K, Ansorge S, Brocke S (2003). "The role of dipeptidyl peptidase IV (DP IV) enzymatic activity in T cell activation and autoimmunity". Biological Chemistry. 383 (7–8): 1133–8. S2CID 30027839.
- Sato K, Dang NH (March 2003). "CD26: a novel treatment target for T-cell lymphoid malignancies? (Review)". International Journal of Oncology. 22 (3): 481–97. PMID 12579300.)
{{cite journal}}
: CS1 maint: DOI inactive as of January 2024 (link - de Meester I, Lambeir AM, Proost P, Scharpé S (2003). "Dipeptidyl Peptidase IV Substrates". Dipeptidyl Aminopeptidases in Health and Disease. Advances in Experimental Medicine and Biology. Vol. 524. pp. 3–17. PMID 12675218.
- Koch S, Anthonsen D, Skovbjerg H, Sjöström H (2003). "On the role of dipeptidyl peptidase IV in the digestion of an immunodominant epitope in celiac disease". Dipeptidyl Aminopeptidases in Health and Disease. Advances in Experimental Medicine and Biology. Vol. 524. pp. 181–7. PMID 12675238.
- Pro B, Dang NH (October 2004). "CD26/dipeptidyl peptidase IV and its role in cancer". Histology and Histopathology. 19 (4): 1345–51. PMID 15375776.
External links
- The MEROPS online database for peptidases and their inhibitors: S09.003
- Dipeptidyl-Peptidase+IV at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Banting and Best Diabetes Centre at UT dpp4