Diphenylprolinol
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Chemical compound
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Diphenylprolinol (D2PM), or (R/S)-(±)-diphenyl-2-pyrrolidinyl-methanol, is a
norepinephrine-dopamine reuptake inhibitor which is used as a designer drug.[1]
Pharmacology
The dextrorotary (R)-(+)-enantiomer is the more pharmacologically active, although a variety of related derivatives have been studied.[2]
Side effects including chest pain (suggestive of possible cardiovascular toxicity) have been seen following recreational use of diphenylprolinol, although it was combined with
party pill product, thus making it impossible to say for certain which drug was responsible.[3]
Other uses
Diphenylprolinol can be used to prepare the chiral
enantioselective organic synthesis.[4]
See also
- 2-Diphenylmethylpyrrolidine (Desoxy-diphenylprolinol)
- Desoxypipradrol
- Pipradrol
- Prolinol
- Corey-Bakshi-Shibata reduction
References
- S2CID 115828300.
- ^ US patent 5925666, Jackson PF, Slusher BS, "Pharmaceutical compositions and methods for treating compulsive disorders using pyrrolidine derivatives", issued 20 July 1999, assigned to Eisai Corp of North America.
- PMID 18821489.
- ISSN 0002-7863.