Diphenylprolinol

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Diphenylprolinol
Clinical data
ATC code
  • none
Legal status
Legal status
  • DE: NpSG (Industrial and scientific use only)
  • UK: Class B
Identifiers
  • diphenyl(pyrrolidin-2-yl)methanol
JSmol)
  • OC(c1ccccc1)(c2ccccc2)C3NCCC3
  • InChI=1S/C17H19NO/c19-17(16-12-7-13-18-16,14-8-3-1-4-9-14)15-10-5-2-6-11-15/h1-6,8-11,16,18-19H,7,12-13H2 checkY
  • Key:OGCGXUGBDJGFFY-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Diphenylprolinol (D2PM), or (R/S)-(±)-diphenyl-2-pyrrolidinyl-methanol, is a

norepinephrine-dopamine reuptake inhibitor which is used as a designer drug.[1]

Pharmacology

The dextrorotary (R)-(+)-enantiomer is the more pharmacologically active, although a variety of related derivatives have been studied.[2]

Side effects including chest pain (suggestive of possible cardiovascular toxicity) have been seen following recreational use of diphenylprolinol, although it was combined with

party pill product, thus making it impossible to say for certain which drug was responsible.[3]

Other uses

Diphenylprolinol can be used to prepare the chiral

enantioselective organic synthesis.[4]

See also

References

  1. S2CID 115828300
    .
  2. ^ US patent 5925666, Jackson PF, Slusher BS, "Pharmaceutical compositions and methods for treating compulsive disorders using pyrrolidine derivatives", issued 20 July 1999, assigned to Eisai Corp of North America. 
  3. PMID 18821489
    .
  4. .