Diphenylpyraline

Source: Wikipedia, the free encyclopedia.
Diphenylpyraline
Topical
ATC code
Legal status
Legal status
  • In general: ℞ (Prescription only)
Pharmacokinetic data
Elimination half-life24–40 hours[1]
Identifiers
  • 4-benzhydryloxy-1-methyl-piperidine
JSmol)
  • O(C(c1ccccc1)c2ccccc2)C3CCN(C)CC3
  • InChI=1S/C19H23NO/c1-20-14-12-18(13-15-20)21-19(16-8-4-2-5-9-16)17-10-6-3-7-11-17/h2-11,18-19H,12-15H2,1H3 checkY
  • Key:OWQUZNMMYNAXSL-UHFFFAOYSA-N checkY
  (verify)

Diphenylpyraline (DPP; sold as Allergen, Arbid, Belfene, Diafen, Hispril, Histyn, Lergobine, Lyssipol, Mepiben, Neargal) is a

hyperactivity in rodents.[6] It has been shown to be useful in the treatment of Parkinsonism.[7]

Synthesis

Diphenylpyraline synthesis via coupling of 4-hydroxy-1-methylpiperidine with benzhydrylbromide[8][9]

References

  1. S2CID 38955052
    .
  2. ^
    ISBN 3-88763-075-0
    .
  3. ^
    S2CID 19330175
    .
  4. PMID 2884340
    .
  5. ISBN 0-444-52166-6
    .
  6. PMID 15627433
    .
  7. S2CID 35946097
    .
  8. ^ US 2479843, Knox LH, Kapp R, "1-Alkylpiperidyl-4-benzhydryl ethers, acid salts thereof and their preparation", issued 23 August 1949, assigned to Nopco Chemical Company. 
  9. ^ DE 934890, Schuler WA, "Verfahren zur Herstellung von basischen Benzhydryläthern [Process for the production of basic benzhydrylethers]", issued 10 November 1955, assigned to Chemische Fabrik Promonta LLC.