Diphtheria antitoxin

Source: Wikipedia, the free encyclopedia.
Diphtheria antitoxin
Vial of 10,000 units, circa 1925.
Clinical data
AHFS/Drugs.comMicromedex Detailed Consumer Information
Routes of
administration
IM, IV
ATC code
Identifiers
ChemSpider
  • none

Diphtheria antitoxin (DAT) is a medication made up of

injection into a vein or muscle.[2]

Side effects are common.

allergic reactions including anaphylaxis.[2] Diphtheria antitoxin is made from the blood plasma of horses that have been immunized against diphtheria toxin.[1] It works by neutralizing the toxins produced by Corynebacterium diphtheriae.[1]

Diphtheria antitoxin was developed and came into medical use in the late 1800s.

U.S. territory of Alaska across 674 miles (1,085 km) in 5+12 days, saving the small town of Nome
and the surrounding communities from an epidemic of the disease.

Diphtheria antitoxin is on the

Centers for Disease Control.[1] It is not available in many countries including many in Europe as of 2008.[10]

Chemistry

One of the first bottles of Diphtheria antitoxin produced by the Hygienic Laboratory (predecessor of the NIH), c. 1895

It is a solution of concentrated proteins, chiefly

antibodies obtained from the blood of horses that have been immunized against diphtheria toxin.[1]

References

  1. ^ a b c d e "Our Formulary | Infectious Diseases Laboratories | CDC". www.cdc.gov. 22 September 2016. Archived from the original on 16 December 2016. Retrieved 9 December 2016.
  2. ^ .
  3. ^ .
  4. from the original on 2017-09-23.
  5. ^ "The St. Louis Tragedy and Enactment of the 1902 Biologics Control Act". U.S. Food and Drug Administration. April 9, 2009. Archived from the original on February 18, 2014.
  6. ^ "100 Years of Biologics Regulation" (PDF). U.S. Food and Drug Administration. April 21, 2009.
  7. ^ "Science and the Regulation of Biological Products". U.S. Food and Drug Administration. April 9, 2009.
  8. . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  9. . WHO/MHP/HPS/EML/2021.02.
  10. .

External links