Dystroglycan
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Dystroglycan is a protein that in humans is encoded by the DAG1 gene.[5][6][7]
Dystroglycan is one of the
exons that are separated by a large intron
. The spliced exons code for a protein product that is finally cleaved into two non-covalently associated subunits, [alpha] (N-terminal) and [beta] (C-terminal).
Function
In skeletal muscle the dystroglycan complex works as a transmembrane linkage between the extracellular matrix and the cytoskeleton. [alpha]-dystroglycan is extracellular and binds to merosin
Ras
-related signal pathway, can interact with the cytoplasmic domain of dystroglycan.
Expression
Dystroglycan is widely distributed in non-muscle tissues as well as in muscle tissues. During epithelial morphogenesis of kidney, the dystroglycan complex is shown to act as a receptor for the basement membrane. Dystroglycan expression in Mus musculus brain and neural retina has also been reported. However, the physiological role of dystroglycan in non-muscle tissues remains unclear.
In December 2022, the implications of abnormal dystroglycan expression and/or O-mannosylation on the pathogenesis of cancer have been reviewed.[9]
Interactions
Dystroglycan has been shown to
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000173402 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000039952 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 7774920.
- S2CID 4273337.
- ^ "Entrez Gene: DAG1 dystroglycan 1 (dystrophin-associated glycoprotein 1)".
- PMID 15071496.
- PMID 36494657.
- ^ PMID 11724572.
- PMID 7744812.
- PMID 10988290.
Further reading
- Matsumura K, Tomé FM, Collin H, Azibi K, Chaouch M, Kaplan JC, et al. (September 1992). "Deficiency of the 50K dystrophin-associated glycoprotein in severe childhood autosomal recessive muscular dystrophy". Nature. 359 (6393): 320–322. S2CID 4326618.
- Apel ED, Roberds SL, Campbell KP, Merlie JP (July 1995). "Rapsyn may function as a link between the acetylcholine receptor and the agrin-binding dystrophin-associated glycoprotein complex". Neuron. 15 (1): 115–126. S2CID 589282.
- Yang B, Jung D, Motto D, Meyer J, Koretzky G, Campbell KP (May 1995). "SH3 domain-mediated interaction of dystroglycan and Grb2". The Journal of Biological Chemistry. 270 (20): 11711–11714. PMID 7744812.
- Yamada H, Shimizu T, Tanaka T, Campbell KP, Matsumura K (September 1994). "Dystroglycan is a binding protein of laminin and merosin in peripheral nerve". FEBS Letters. 352 (1): 49–53. S2CID 17529055.
- Gee SH, Montanaro F, Lindenbaum MH, Carbonetto S (June 1994). "Dystroglycan-alpha, a dystrophin-associated glycoprotein, is a functional agrin receptor". Cell. 77 (5): 675–686. S2CID 54232250.
- Ibraghimov-Beskrovnaya O, Milatovich A, Ozcelik T, Yang B, Koepnick K, Francke U, Campbell KP (October 1993). "Human dystroglycan: skeletal muscle cDNA, genomic structure, origin of tissue specific isoforms and chromosomal localization". Human Molecular Genetics. 2 (10): 1651–1657. PMID 8268918.
- Yamada H, Denzer AJ, Hori H, Tanaka T, Anderson LV, Fujita S, et al. (September 1996). "Dystroglycan is a dual receptor for agrin and laminin-2 in Schwann cell membrane". The Journal of Biological Chemistry. 271 (38): 23418–23423. PMID 8798547.
- Tian M, Jacobson C, Gee SH, Campbell KP, Carbonetto S, Jucker M (December 1996). "Dystroglycan in the cerebellum is a laminin alpha 2-chain binding protein at the glial-vascular interface and is expressed in Purkinje cells". The European Journal of Neuroscience. 8 (12): 2739–2747. S2CID 1707823.
- Matsumura K, Chiba A, Yamada H, Fukuta-Ohi H, Fujita S, Endo T, et al. (May 1997). "A role of dystroglycan in schwannoma cell adhesion to laminin". The Journal of Biological Chemistry. 272 (21): 13904–13910. PMID 9153251.
- Pirozzi G, McConnell SJ, Uveges AJ, Carter JM, Sparks AB, Kay BK, Fowlkes DM (June 1997). "Identification of novel human WW domain-containing proteins by cloning of ligand targets". The Journal of Biological Chemistry. 272 (23): 14611–14616. PMID 9169421.
- Lorenzo LE, Godin AG, Wang F, St-Louis M, Carbonetto S, Wiseman PW, et al. (June 2014). "Gephyrin clusters are absent from small diameter primary afferent terminals despite the presence of GABA(A) receptors". The Journal of Neuroscience. 34 (24): 8300–8317. PMID 24920633.
- Gesemann M, Brancaccio A, Schumacher B, Ruegg MA (January 1998). "Agrin is a high-affinity binding protein of dystroglycan in non-muscle tissue". The Journal of Biological Chemistry. 273 (1): 600–605. PMID 9417121.
- Rambukkana A, Yamada H, Zanazzi G, Mathus T, Salzer JL, Yurchenco PD, et al. (December 1998). "Role of alpha-dystroglycan as a Schwann cell receptor for Mycobacterium leprae". Science. 282 (5396): 2076–2079. PMID 9851927.
- Cao W, Henry MD, Borrow P, Yamada H, Elder JH, Ravkov EV, et al. (December 1998). "Identification of alpha-dystroglycan as a receptor for lymphocytic choriomeningitis virus and Lassa fever virus". Science. 282 (5396): 2079–2081. PMID 9851928.
- Shimizu H, Hosokawa H, Ninomiya H, Miner JH, Masaki T (April 1999). "Adhesion of cultured bovine aortic endothelial cells to laminin-1 mediated by dystroglycan". The Journal of Biological Chemistry. 274 (17): 11995–12000. PMID 10207021.
- Côté PD, Moukhles H, Lindenbaum M, Carbonetto S (November 1999). "Chimaeric mice deficient in dystroglycans develop muscular dystrophy and have disrupted myoneural synapses". Nature Genetics. 23 (3): 338–342. S2CID 564897.
- Rentschler S, Linn H, Deininger K, Bedford MT, Espanel X, Sudol M (April 1999). "The WW domain of dystrophin requires EF-hands region to interact with beta-dystroglycan". Biological Chemistry. 380 (4): 431–442. S2CID 24598356.
- Tommasi di Vignano A, Di Zenzo G, Sudol M, Cesareni G, Dente L (April 2000). "Contribution of the different modules in the utrophin carboxy-terminal region to the formation and regulation of the DAP complex". FEBS Letters. 471 (2–3): 229–234. S2CID 21529759.
- James M, Nuttall A, Ilsley JL, Ottersbach K, Tinsley JM, Sudol M, Winder SJ (May 2000). "Adhesion-dependent tyrosine phosphorylation of (beta)-dystroglycan regulates its interaction with utrophin". Journal of Cell Science. 113 ( Pt 10) (10): 1717–1726. PMID 10769203.
- Russo K, Di Stasio E, Macchia G, Rosa G, Brancaccio A, Petrucci TC (July 2000). "Characterization of the beta-dystroglycan-growth factor receptor 2 (Grb2) interaction". Biochemical and Biophysical Research Communications. 274 (1): 93–98. PMID 10903901.
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External links
- Dystroglycans at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview at sdbonline.org