E2F1
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| Location (UCSC) | Chr 20: 33.68 – 33.69 Mb | Chr 2: 154.4 – 154.41 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
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Transcription factor E2F1 is a protein that in humans is encoded by the E2F1 gene.[5]
Function
The protein encoded by this gene is a member of the E2F family of
DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F2 and E2F3, have an additional cyclin binding domain. This protein binds preferentially to retinoblastoma protein pRB in a cell-cycle dependent manner. It can mediate both cell proliferation and p53-dependent/independent apoptosis.[6]
Transcription
E2F1 promoter[PAX8] => E2F1[7]
Interactions
E2F1 has been shown to
interact
with:
See also
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000101412 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000027490 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- PMID 8964493.
- ^ "Entrez Gene: E2F1 E2F transcription factor 1".
- PMID 21602887.
- ^ PMID 9780002.
- ^ S2CID 8884226.
- PMID 10022926.
- PMID 7969176.
- PMID 10428966.
- S2CID 38805122.
- PMID 14638867.
- ^ PMID 9422723.
- PMID 14593116.
- PMID 11042687.
- PMID 10597240.
- PMID 14637159.
- PMID 14500729.
- PMID 12065415.
- PMID 10523633.
- ^ PMID 8230483.
- PMID 11470869.
- PMID 12397079.
- ^ PMID 8896460.
- PMID 10869426.
- ^ PMID 7739537.
- PMID 7534293.
- ^ PMID 10547281.
- PMID 8657142.
- PMID 8657141.
- PMID 7892279.
- PMID 8405995.
- PMID 12697828.
- S2CID 29407635.
- PMID 18367454.
Further reading
- Dupont E, Sansal I, Toru D, Evrard C, Rouget P (1997). "[Identification of NPDC-1, gene involved in the control of proliferation and differentiation of neural and glial precursors]". C. R. Séances Soc. Biol. Fil. 191 (1): 95–104. PMID 9181131.
- Stevens C, La Thangue NB (2005). "The emerging role of E2F-1 in the DNA damage response and checkpoint control". DNA Repair (Amst.). 3 (8–9): 1071–9. PMID 15279795.
- Zhang Z, Wang H, Li M, Rayburn E, Agrawal S, Zhang R (2006). "Novel MDM2 p53-independent functions identified through RNA silencing technologies". Ann. N. Y. Acad. Sci. 1058 (1): 205–14. S2CID 35683657.
- Schild C, Wirth M, Reichert M, Schmid RM, Saur D, Schneider G (July 2009). "PI3K signaling maintains c-myc expression to regulate transcription of E2F1 in pancreatic cancer cells". Mol. Carcinog. 48 (12): 1149–58. S2CID 41545085.
External links
- E2F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- FactorBook E2F1
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This article incorporates text from the United States National Library of Medicine, which is in the public domain.