E4F1

Source: Wikipedia, the free encyclopedia.
E4F1
Identifiers
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_001288776
NM_001288778
NM_004424

NM_001301784
NM_007893
NM_001355708

RefSeq (protein)

NP_001275705
NP_001275707
NP_004415

NP_001288713
NP_031919
NP_001342637

Location (UCSC)Chr 16: 2.22 – 2.24 MbChr 17: 24.66 – 24.69 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[5][6][7]

Function

The

zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[7]

Interactions

E4F1 has been shown to

interact
with:

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000167967 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024137 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. S2CID 46826484
    .
  6. .
  7. ^ a b "Entrez Gene: E4F1 E4F transcription factor 1".
  8. ^
    PMID 12446718
    .
  9. .
  10. .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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