E4F1
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RefSeq (mRNA) | |||||||||
RefSeq (protein) | |||||||||
Location (UCSC) | Chr 16: 2.22 – 2.24 Mb | Chr 17: 24.66 – 24.69 Mb | |||||||
PubMed search | [3] | [4] |
View/Edit Human | View/Edit Mouse |
Transcription factor E4F1 is a protein that in humans is encoded by the E4F1 gene.[5][6][7]
Function
The
zinc finger protein encoded by this gene is one of several cellular transcription factors whose DNA-binding activities are regulated through the action of adenovirus E1A. A 50-kDa amino-terminal product is generated from the full-length protein through proteolytic cleavage. The protein is differentially regulated by E1A-induced phosphorylation. The full-length gene product represses transcription from the E4 promoter in the absence of E1A, while the 50-kDa form acts as a transcriptional activator in its presence.[7]
Interactions
E4F1 has been shown to
interact
with:
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000167967 - Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000024137 - Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- S2CID 46826484.
- PMID 8828041.
- ^ a b "Entrez Gene: E4F1 E4F transcription factor 1".
- ^ PMID 12446718.
- PMID 10644996.
- PMID 10869426.
Further reading
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–174. PMID 8125298.
- Fernandes ER, Rooney RJ (1997). "The adenovirus E1A-regulated transcription factor E4F is generated from the human homolog of nuclear factor phiAP3". Mol. Cell. Biol. 17 (4): 1890–1903. PMID 9121437.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–156. PMID 9373149.
- Rooney RJ, Daniels RR, Jenkins NA, Gilbert DJ, Rothammer K, Morris SW, Higgs DR, Copeland NG (1998). "Chromosomal location and tissue expression of the gene encoding the adenovirus E1A-regulated transcription factor E4F in humans and mice". Mamm. Genome. 9 (4): 320–323. S2CID 31200297.
- Kim ST, Lim DS, Canman CE, Kastan MB (2000). "Substrate specificities and identification of putative substrates of ATM kinase family members". J. Biol. Chem. 274 (53): 37538–37543. PMID 10608806.
- Sandy P, Gostissa M, Fogal V, Cecco LD, Szalay K, Rooney RJ, Schneider C, Del Sal G (2000). "p53 is involved in the p120E4F-mediated growth arrest". Oncogene. 19 (2): 188–199. PMID 10644996.
- Fajas L, Paul C, Zugasti O, Le Cam L, Polanowska J, Fabbrizio E, Medema R, Vignais ML, Sardet C (2000). "pRB binds to and modulates the transrepressing activity of the E1A-regulated transcription factor p120E4F". Proc. Natl. Acad. Sci. U.S.A. 97 (14): 7738–7743. PMID 10869426.
- Rizos H, Diefenbach E, Badhwar P, Woodruff S, Becker TM, Rooney RJ, Kefford RF (2003). "Association of p14ARF with the p120E4F transcriptional repressor enhances cell cycle inhibition". J. Biol. Chem. 278 (7): 4981–4989. PMID 12446718.
- Fenton SL, Dallol A, Agathanggelou A, Hesson L, Ahmed-Choudhury J, Baksh S, Sardet C, Dammann R, Minna JD, Downward J, Maher ER, Latif F (2004). "Identification of the E1A-regulated transcription factor p120 E4F as an interacting partner of the RASSF1A candidate tumor suppressor gene". Cancer Res. 64 (1): 102–107. S2CID 13897912.
- Nakamura Y, Igarashi K, Suzuki T, Kanno J, Inoue T, Tazawa C, Saruta M, Ando T, Moriyama N, Furukawa T, Ono M, Moriya T, Ito K, Saito H, Ishibashi T, Takahashi S, Yamada S, Sasano H (2005). "E4F1, a novel estrogen-responsive gene in possible atheroprotection, revealed by microarray analysis". Am. J. Pathol. 165 (6): 2019–2031. PMID 15579445.
- Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, S2CID 4427026.
- Paul C, Lacroix M, Iankova I, Julien E, Schäfer BW, Labalette C, Wei Y, Le Cam A, Le Cam L, Sardet C (2006). "The LIM-only protein FHL2 is a negative regulator of E4F1". Oncogene. 25 (40): 5475–5484. S2CID 19655591.
- Le Cam L, Linares LK, Paul C, Julien E, Lacroix M, Hatchi E, Triboulet R, Bossis G, Shmueli A, Rodriguez MS, Coux O, Sardet C (2006). "E4F1 is an atypical ubiquitin ligase that modulates p53 effector functions independently of degradation". Cell. 127 (4): 775–788. S2CID 542082.
- Cvetanovic M, Rooney RJ, Garcia JJ, Toporovskaya N, Zoghbi HY, Opal P (2007). "The role of LANP and ataxin 1 in E4F-mediated transcriptional repression". EMBO Rep. 8 (7): 671–677. PMID 17557114.
External links
- E4F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.