Eccrine sweat gland

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Eccrine sweat gland
A sectional view of the skin (magnified), with eccrine glands highlighted.
Details
PrecursorEctoderm[1]
SystemIntegumentary[1]
NerveCholinergic sympathetic nerves[2]
Identifiers
Latinglandula sudorifera merocrina;
glandula sudorifera eccrina
MeSHD004439
THH3.12.00.3.03009
FMA59154
Anatomical terminology

Eccrine sweat glands (

sweat, a merocrine secretion which is clear, odorless substance, consisting primarily of water. These are present from birth. Their secretory part is present deep inside the dermis
.

Eccrine glands are composed of an intraepidermal spiral duct, the "acrosyringium"; a dermal duct, consisting of a straight and coiled portion; and a secretory tubule, coiled deep in the

hypodermis.[7] The eccrine gland opens out through the sweat pore. The coiled portion is formed by two concentric layers of columnar or cuboidal epithelial cells.[8] The epithelial cells are interposed by the myoepithelial cells. Myoepithelial cells support the secretory epithelial cells. The duct of eccrine gland is formed by two layers of cuboidal epithelial cells.[9]

Eccrine glands are active in thermoregulation by providing cooling from water evaporation of sweat secreted by the glands on the body surface and emotionally induced sweating (anxiety, fear, stress, and pain).[6][7] The white sediment in otherwise colorless eccrine secretions is caused by evaporation that increases the concentration of salts.

The odor from sweat is due to bacterial activity on the secretions of the

apocrine sweat glands
, a distinctly different type of sweat gland found in human skin.

innervated only by the sympathetic nervous system. Postganglionic sympathetic fibers innervating the cutaneous district can produce either noradrenaline or acetylcholine as neurotransmitters depending on the target structure.[10] The sympathetic cholinergic fibers connecting with the sweat glands discharge primarily by changes in deep body temperature (core temperature).[11]
The glands on palms and soles do not respond only to temperature stimuli but secrete at times of emotional stress.

Secretion

The secretion of eccrine glands is a sterile, dilute

immunoglobulins, antimicrobial peptides such as dermcidin, and many others.[6][12]

Relative to the plasma and extracellular fluid, the concentration of Na+ ions is much lower in sweat (~40 mM in sweat versus ~140 mM in plasma and extracellular fluid). Initially, within the eccrine glands, sweat has a high concentration of Na+ ions. The Na+ ions are re-absorbed into the tissue via the

epithelial sodium channels (ENaCs) that are located on the apical membrane of the cells that form the eccrine gland ducts (see Fig. 9 and Fig. 10 of the reference).[9] This re-uptake of Na+ ions reduces the loss of Na+ during the process of perspiration. People with the systemic pseudohypoaldosteronism syndrome who carry mutations in the ENaC subunit genes have salty sweat as they cannot reabsorb the salt in sweat.[13][14] Sometimes these Na+ ion concentrations can greatly increase (up to 180 mmol/L).[13]
[15]

In people who have

CFTR chloride transporter that is also located on the apical membrane of eccrine gland ducts.[9]

See also

List of distinct cell types in the adult human body

References

  1. ^ a b Neas, John F. "Development of the Integumentary System". In Martini, Frederic H.; Timmons, Michael J.; Tallitsch, Bob (eds.). Embryology Atlas (4th ed.). Benjamin Cumings. Archived from the original on 2012-08-08. Retrieved 2012-12-21.
  2. ISBN 9783540536666
    .
  3. ISBN 9780195170771
    .
  4. ^ "our weird lack of hair may be the key to our success".
  5. ISBN 978-0-7216-2921-6
    .
  6. ^ a b c d Bolognia, J., Jorizzo, J., & Schaffer, J. (2012). Dermatology (3rd ed., pp. 539-544). [Philadelphia]: Elsevier Saunders.
  7. ^
    S2CID 205556581
    .
  8. PMID 26014472
    .
  9. ^
    S2CID 8504408
    .
  10. ^ Donadio, V., Incensi, A., Vacchiano, V. et al. The autonomic innervation of hairy skin in humans: an in vivo confocal study. Sci Rep 9, 16982 (2019). https://doi.org/10.1038/s41598-019-53684-3
  11. ^ Neural control of sweat secretion: a review* Y. Hu, C. Converse, M.C. Lyons and W.H. Hsu iD Department of Biomedical Sciences, Iowa State University, 1800 S. 16th Street, Ames, IA 50011-1250, U.S.A. Linked Comment: Morris-Jones. Br J Dermatol 2018; 178:1233–1234
  12. S2CID 26601547
    .
  13. ^
    PMID 1939532
    .
  14. PMID 26772908
    .
  15. S2CID 9564777
    .

External links
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