Edivoxetine

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Edivoxetine
Clinical data
ATC code
  • None
Legal status
Legal status
  • Development terminated
Identifiers
  • (1R)-2-(5-fluoro-2-methoxyphenyl)-1-[(2S)-morpholin-2-yl]-1-(tetrahydro-2H-pyran-4-yl)ethanol
JSmol)
  • COC1=C(C=C(C=C1)F)C[C@]([C@@H]2CNCCO2)(C3CCOCC3)O
  • InChI=1S/C18H26FNO4/c1-22-16-3-2-15(19)10-13(16)11-18(21,14-4-7-23-8-5-14)17-12-20-6-9-24-17/h2-3,10,14,17,20-21H,4-9,11-12H2,1H3/t17-,18+/m0/s1
  • Key:CPBHSHYQQLFAPW-ZWKOTPCHSA-N

Edivoxetine (

phase III clinical trials in 2012 for major depressive disorder, but failed to get approval.[1][3]

Effectiveness

In a study published in 2010, edivoxetine succeeded to prove superiority over placebo, as measured by

Hamilton Depression Rating Scale. However, effectiveness could be observed using the Self-Rated Quick Inventory of Depressive Symptomatology.[4]

In a study published in 2011, using the Montgomery–Åsberg Depression Rating Scale and the Sheehan Disability Scale, edivoxetine showed superiority over placebo, with higher response and remission rates.[5]

In December 2013, Eli Lilly announced that the clinical development of edivoxetine will be stopped due to lack of efficacy compared to SSRI alone in three separate clinical trials.[6]

Side effects

Side effects significantly associated with edivoxetine are headache, nausea, constipation, dry mouth and insomnia.[4]

The above-mentioned studies report increases of the

cardiac rhythm, and one also increases of diastolic and systolic blood pressures.[4][5]

See also

References

  1. ^
    doi:10.1176/pn.47.5.psychnews_47_5_1-b. Retrieved 2012-04-27. {{cite journal}}: Unknown parameter |agency= ignored (help
    )
  2. ^ "Statement on a nonproprietary name adopted by the USAN council - Edivoxetine" (PDF) (Press release). American Medical Association. 2012. Retrieved 2012-04-12.
  3. S2CID 3194093
    .
  4. ^
    PMID 19909980
    .
  5. ^
    PMID 21511276
    .
  6. ^ "Lilly Announces Edivoxetine Did Not Meet Primary Endpoint of Phase III Clinical Studies as Add-On Therapy for Major Depressive Disorder | Eli Lilly and Company".
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