Effects of high altitude on humans
The effects of high altitude on humans are mostly the consequences of reduced partial pressure of oxygen in the atmosphere. The medical problems that are direct consequence of high altitude are caused by the low inspired partial pressure of oxygen, which is caused by the reduced atmospheric pressure, and the constant gas fraction of oxygen in atmospheric air over the range in which humans can survive.[1] The other major effect of altitude is due to lower ambient temperature.
The
The physiological responses to high altitude include hyperventilation, polycythemia, increased capillary density in muscle and hypoxic pulmonary vasoconstriction–increased intracellular oxidative enzymes. There are a range of responses to hypoxia at the cellular level, shown by discovery of hypoxia-inducible factors (HIFs), which determine the general responses of the body to oxygen deprivation. Physiological functions at high altitude are not normal and evidence also shows impairment of neuropsychological function, which has been implicated in mountaineering and aviation accidents.[1] Methods of mitigating the effects of the high altitude environment include oxygen enrichment of breathing air and/or an increase of pressure in an enclosed environment.[1] Other effects of high altitude include frostbite, hypothermia, sunburn, and dehydration.
Tibetans and Andeans are two groups which are relatively well adapted to high altitude, but display noticeably different phenotypes.[1]
Pressure effects as a function of altitude
The human body can perform best at
Atmospheric pressure decreases following the
Mountain medicine recognizes three altitude regions which reflect the lowered amount of oxygen in the atmosphere:[11]
- High altitude = 1,500–3,500 metres (4,900–11,500 ft)
- Very high altitude = 3,500–5,500 metres (11,500–18,000 ft)
- Extreme altitude = above 5,500 metres (18,000 ft)
Travel to each of these altitude regions can lead to medical problems, from the mild symptoms of
People who develop acute mountain sickness can sometimes be identified before the onset of symptoms by changes in fluid balance hormones regulating salt and water metabolism. People who are predisposed to develop high-altitude pulmonary edema may present a reduction in urine production before respiratory symptoms become apparent. [15]
Humans have survived for two years at 5,950 m (19,520 ft, 475 millibars of atmospheric pressure), which is the highest recorded permanently tolerable altitude; the highest permanent settlement known, La Rinconada, is at 5,100 m (16,700 ft).[16]
At altitudes above 7,500 m (24,600 ft, 383 millibars of atmospheric pressure), sleeping becomes very difficult, digesting food is near-impossible, and the risk of HAPE or HACE increases greatly.[12][17][18]
Death zone
The
Many deaths in high-altitude mountaineering have been caused by the effects of the death zone, either directly by loss of vital functions or indirectly through wrong decisions made under stress or physical weakening leading to accidents. In the death zone, the human body cannot acclimatize. An extended stay in the death zone without
At an altitude of 19,000 m (63,000 ft), the
Even below the Armstrong limit, an abrupt decrease in atmospheric pressure can cause venous gas bubbles and decompression sickness. A sudden change from sea-level pressure to pressures as low as those at 5,500 m (18,000 ft) can cause altitude-induced decompression sickness.[22]
Acclimatization
The human body can adapt to high altitude through both immediate and long-term acclimatization. At high altitude, in the short term, the lack of oxygen is sensed by the
In addition, at high altitude, the
Full acclimatization requires days or even weeks. Gradually, the body compensates for the respiratory alkalosis by renal excretion of bicarbonate, allowing adequate respiration to provide oxygen without risking alkalosis. It takes about four days at any given altitude and can be enhanced by drugs such as
Pulmonary artery pressure increases in an effort to oxygenate more blood.Full hematological adaptation to high altitude is achieved when the increase of red blood cells reaches a plateau and stops. The length of full hematological adaptation can be approximated by multiplying the altitude in kilometres by 11.4 days. For example, to adapt to 4,000 metres (13,000 ft) of altitude would require 45.6 days.[27] The upper altitude limit of this linear relationship has not been fully established.[6][16]
Even when acclimatized, prolonged exposure to high altitude can interfere with pregnancy and cause intrauterine growth restriction or pre-eclampsia.[28] High altitude causes decreased blood flow to the placenta, even in acclimatized women, which interferes with fetal growth.[28] Consequently, children born at high-altitudes are found to be born shorter on average than children born at sea level.[29]
Adaptation
It is estimated that 81.6 million people live at elevations above 2,500 metres (8,200 ft).[30] Genetic changes have been detected in high-altitude population groups in
Compared with acclimatized newcomers, native Andean and Himalayan populations have better oxygenation at birth, enlarged lung volumes throughout life, and a higher capacity for exercise.[1] Tibetans demonstrate a sustained increase in cerebral blood flow, elevated resting ventilation, lower hemoglobin concentration (at elevations below 4000 metres),[34] and less susceptibility to chronic mountain sickness (CMS).[1][35] Andeans possess a similar suite of adaptations but exhibit elevated hemoglobin concentration and a normal resting ventilation.[36] These adaptations may reflect the longer history of high altitude habitation in these regions.[37][38]
A lower
Mitigation
Mitigation may be by supplementary oxygen, pressurisation of the habitat or environmental protection suit, or a combination of both. In all cases the critical effect is the raising of oxygen partial pressure in the breathing gas.[1]
Room air at altitude can enriched with oxygen without introducing an unacceptable fire hazard. At an altitude of 8000 m the equivalent altitude in terms of oxygen partial pressure can be reduced to below 4000 m without increasing the fire hazard beyond that of normal sea level atmospheric air. In practice this can be done using oxygen concentrators.[43]
Other hazards
The ambient air temperature is predictably affected by altitude, and this also has physiological effects on people exposed to high altitudes. The temperature effects and their mitigation are not inherently different from temperature effects from other causes, but the effects of temperature and pressure are cumulative.
The temperature of the atmosphere decreases by a
In addition to cold injuries, breathing cold air can cause dehydration, because the air is warmed to body temperature and humidified from body moisture.[15]
There is also a higher risk of
Athletic performance
For athletes, high altitude produces two contradictory effects on performance. For explosive events (sprints up to 400 metres, long jump, triple jump) the reduction in atmospheric pressure means there is less resistance from the atmosphere and the athlete's performance will generally be better at high altitude.[53] For endurance events (races of 800 metres or more), the predominant effect is the reduction in oxygen, which generally reduces the athlete's performance at high altitude.[54] One way to gauge this reduction is by monitoring VO2max, a measurement of the maximum capacity of an individual to utilize O2 during strenuous exercise. For an unacclimated individual, VO2max begins to decrease significantly at moderate elevation, starting at 1,500 metres and dropping 8 to 11 percent for every additional 1000 metres.[55]
Explosive events
Sports organizations acknowledge the effects of altitude on performance: for example, the governing body for the
An elite athletics meeting was held annually in Sestriere, Italy, from 1988 to 1996, and again in 2004. The advantage of its high altitude in sprinting and jumping events held out hope of world records, with sponsor Ferrari offering a car as a bonus.[56][57] One record was set, in the men's pole vault by Sergey Bubka in 1994;[57] the men's and women's records in long jump were also beaten, but wind assisted.[58]
Endurance events
Athletes can also take advantage of altitude acclimatization to increase their performance.[10] The same changes that help the body cope with high altitude increase performance back at sea level. However, this may not always be the case. Any positive acclimatization effects may be negated by a de-training effect as the athletes are usually not able to exercise with as much intensity at high altitudes compared to sea level.[59]
This conundrum led to the development of the altitude training modality known as "Live-High, Train-Low", whereby the athlete spends many hours a day resting and sleeping at one (high) altitude, but performs a significant portion of their training, possibly all of it, at another (lower) altitude. A series of studies conducted in Utah in the late 1990s showed significant performance gains in athletes who followed such a protocol for several weeks.[59][60] Another study from 2006 has shown performance gains from merely performing some exercising sessions at high altitude, yet living at sea level.[61]
The performance-enhancing effect of altitude training could be due to increased red blood cell count,[62] more efficient training,[63] or changes in muscle physiology.[64][65]
In 2007, FIFA issued a short-lived moratorium on international football matches held at more than 2,500 metres above sea level, effectively barring select stadiums in Bolivia, Colombia, and Ecuador from hosting World Cup qualifiers, including their capital cities.[66] In their ruling, FIFA's executive committee specifically cited what they believed to be an unfair advantage possessed by home teams acclimated to the elevation. The ban was reversed in 2008.[66]
See also
- 1996 Mount Everest disaster
- 1999 South Dakota Learjet crash
- 2008 K2 disaster
- 2,3-bisphosphoglyceric acid, adaptation to chronic hypoxia
- Altitude sickness
- Altitude tent
- Aviation medicine
- Gamow bag
- Helios Airways Flight 522
- High-altitude adaptation
- Hypoxemia
- Hypoxia (medical)
- Mars habitat
- Organisms at high altitude
- Oxygen–hemoglobin dissociation curve
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External links
- Nosek, Thomas M. "Section 4/4ch7/s4ch7_32". Essentials of Human Physiology. Archived from the original on 24 March 2016.
- IPPA, High Altitude Pathology Institute.