Electroconvulsive therapy

Electroconvulsive therapy (ECT) or electroshock therapy (EST) is a

ECT is often used as an intervention for major depressive disorder, mania, and catatonia.^[4] The usual course of ECT involves multiple administrations, typically given two or three times per week until the patient no longer has symptoms. ECT is administered under anesthesia with a muscle relaxant.^[7] ECT can differ in its application in three ways: electrode placement, treatment frequency, and the electrical waveform of the stimulus. These treatment parameters can pose significant differences in both adverse side effects and symptom remission in the treated patient.

Placement can be bilateral, where the electric current is passed from one side of the brain to the other, or unilateral, in which the current is solely passed across one

As early as the 16th century, agents to induce seizures were used to treat psychiatric conditions. In 1785, the therapeutic use of seizure induction was documented in the

A positive side effect to the treatment was retrograde amnesia. It was because of this side effect that patients could not remember the treatments and had no ill feelings toward it.^[19]

ECT soon replaced metrazol therapy all over the world because it was cheaper, less frightening and more convenient.^[20] Cerletti and Bini were nominated for a Nobel Prize but did not receive one. By 1940, the procedure was introduced to both England and the US. In Germany and Austria, it was promoted by Friedrich Meggendorfer. Through the 1940s and 1950s, the use of ECT became widespread. At the time the ECT device was patented and commercialized abroad, the two Italian inventors had competitive tensions that damaged their relationship.^[21] In the 1960s, despite a climate of condemnation, the original Cerletti-Bini ECT apparatus prototype was contended by scientific museums between Italy and the US.^[22] The ECT apparatus prototype is now owned and displayed by the Sapienza Museum of the History of Medicine in Rome.^[22]

In the early 1940s, in an attempt to reduce the memory disturbance and confusion associated with treatment, two modifications were introduced: the use of unilateral electrode placement and the replacement of

The steady growth of antidepressant use along with negative depictions of ECT in the mass media led to a marked decline in the use of ECT during the 1950s to the 1970s. The Surgeon General stated there were problems with electroshock therapy in the initial years before anesthesia was routinely given, and that "these now-antiquated practices contributed to the negative portrayal of ECT in the popular media."^[24] The New York Times described the public's negative perception of ECT as being caused mainly by one movie: "For Big Nurse in One Flew Over the Cuckoo's Nest, it was a tool of terror, and, in the public mind, shock therapy has retained the tarnished image given it by Ken Kesey's novel: dangerous, inhumane and overused".^[25]

In 1976, Dr. Blatchley demonstrated the effectiveness of his constant current, brief pulse device ECT. This device eventually largely replaced earlier devices because of the reduction in cognitive side effects, although as of 2012 some ECT clinics still were using sine-wave devices.^[26]

The 1970s saw the publication of the first American Psychiatric Association (APA) task force report on electroconvulsive therapy (to be followed by further reports in 1990 and 2001). The report endorsed the use of ECT in the treatment of depression. The decade also saw criticism of ECT.^[27] Specifically, critics pointed to shortcomings such as noted side effects, the procedure being used as a form of abuse, and uneven application of ECT. The use of ECT declined until the 1980s, "when use began to increase amid growing awareness of its benefits and cost-effectiveness for treating severe depression".^[24] In 1985, the National Institute of Mental Health and National Institutes of Health convened a consensus development conference on ECT and concluded that, while ECT was the most controversial treatment in psychiatry and had significant side-effects, it had been shown to be effective for a narrow range of severe psychiatric disorders.^[28]

Because of the backlash noted previously, national institutions reviewed past practices and set new standards. In 1978, the American Psychiatric Association released its first task force report in which new standards for

Though ECT use declined with the advent of modern antidepressants, there has been a resurgence of ECT with new modern technologies and techniques.[30] Modern shock voltage is given for a shorter duration of 0.5 milliseconds where conventional brief pulse is 1.5 milliseconds.^[31]

In a review from 2022 of neuroimaging studies based on a global data collaboration ECT was suggested to work via a temporary disruption of neural circuits followed by augmented neuroplasticity and rewiring.^[32]

Modern use

ECT is used, where possible, with

In 2004, a meta-analytic review paper found in terms of efficacy, "a significant superiority of ECT in all comparisons: ECT versus simulated ECT, ECT versus placebo, ECT versus antidepressants in general, ECT versus tricyclics and ECT versus monoamine oxidase inhibitors."^[43]

In 2003, The UK ECT Review Group published a systematic review and meta-analysis comparing ECT to placebo and antidepressant drugs. This meta-analysis demonstrated a large effect size (high efficacy relative to the mean in terms of the standard deviation) for ECT versus placebo, and versus antidepressant drugs.^[44]

Compared with

The response rate is from 50 to 70% in treatment-resistant patients.[46] Efficacy does not depend on depression subtype.^[37]

Follow-up

There is little agreement on the most appropriate follow-up to ECT for people with major depressive disorder.

Lithium has also been found to reduce the risk of relapse, especially in younger patients.^[48]

Catatonia

ECT is generally a second-line treatment for people with

In adolescents, ECT is highly efficient for several psychiatric disorders, with few and relatively benign adverse effects.[59]^[60][61]

Risk of death

A meta-analysis from 2017 found that the death rate of ECT was around 2.1 per 100,000 procedures.^[62] A review from 2011 reported an estimate of the mortality rate associated with ECT as less than 1 death per 73,440 treatments.^[63]

Cognitive impairment

Cognitive impairment is sometimes noticed after ECT.

The acute effects of ECT can include amnesia, both retrograde (for events occurring before the treatment) and anterograde (for events occurring after the treatment).^[70] Memory loss and confusion are more pronounced with bilateral electrode placement rather than unilateral, and with outdated sine-wave rather than brief-pulse currents. The use of either constant or pulsing electrical impulses also varied the memory loss results in patients. Patients who received pulsing electrical impulses, as opposed to a steady flow, seemed to incur less memory loss. The vast majority of modern treatment uses brief pulse currents.^[70]

Retrograde amnesia is most marked for events occurring in the weeks or months before treatment, with one study showing that although some people lose memories from years prior to treatment, recovery of such memories was "virtually complete" by seven months post-treatment, with the only enduring loss being memories in the weeks and months prior to the treatment.^[71][72] Anterograde memory loss is usually limited to the time of treatment itself or shortly afterwards. In the weeks and months following ECT these memory problems gradually improve, but some people have persistent losses, especially with bilateral ECT.^[1][70] One published review summarizing the results of questionnaires about subjective memory loss found that between 29% and 55% of respondents believed they experienced long-lasting or permanent memory changes.^[73] In 2000, American psychiatrist Sarah Lisanby and colleagues found that bilateral ECT left patients with more persistently impaired memory of public events as compared to right unilateral ECT.^[68]

Effects on brain structure

Considerable controversy exists over the effects of ECT on brain tissue, although a number of mental health associations—including the APA—have concluded that there is no evidence that ECT causes structural brain damage.^[5][40] A 1999 report by the US Surgeon General states: "The fears that ECT causes gross structural brain pathology have not been supported by decades of methodologically sound research in both humans and animals."^[74]

Many expert proponents of ECT maintain that the procedure is safe and does not cause brain damage. Dr. Charles Kellner, a prominent ECT researcher and former chief editor of the Journal of ECT, stated in a 2007 interview that, "There are a number of well-designed studies that show ECT does not cause brain damage and numerous reports of patients who have received a large number of treatments over their lifetime and have suffered no significant problems due to ECT."^[75] Kellner cites a study purporting to show an absence of cognitive impairment in eight subjects after more than 100 lifetime ECT treatments.^[76] Kellner stated "Rather than cause brain damage, there is evidence that ECT may reverse some of the damaging effects of serious psychiatric illness." Two meta-analyses find that ECT is associated with brain matter growth.^[77][78]

Effects in pregnancy

If steps are taken to decrease potential risks, ECT is generally accepted to be relatively safe during all trimesters of pregnancy, particularly when compared to pharmacological treatments.^[6][79] Suggested preparation for ECT during pregnancy includes a pelvic examination, discontinuation of nonessential anticholinergic medication, uterine tocodynamometry, intravenous hydration, and administration of a nonparticulate antacid. During ECT, elevation of the pregnant woman's right hip, external fetal cardiac monitoring, intubation, and avoidance of excessive hyperventilation are recommended.^[6] In many instances of active mood disorder during pregnancy, the risks of untreated symptoms may outweigh the risks of ECT. Potential complications of ECT during pregnancy can be minimized by modifications in technique. The use of ECT during pregnancy requires thorough evaluation of the patient's capacity for informed consent.^[80]

Effects on the heart

ECT can cause a lack of blood flow and oxygen to the heart,

The placement of electrodes, as well as the dose and duration of the stimulation is determined on a per-patient basis.^[1]: 1881

In unilateral ECT, both electrodes are placed on the same side of the patient's head. Unilateral ECT may be used first to minimize side effects such as memory loss.

In bilateral ECT, the two electrodes are placed on opposite sides of the head. Usually bitemporal placement is used, whereby the electrodes are placed on the temples. Uncommonly bifrontal placement is used; this involves positioning the electrodes on the patient's forehead, roughly above each eye.

Unilateral ECT is thought to cause fewer cognitive effects than bilateral treatment, but is less effective unless administered at higher doses.^[1]: 1881 Most patients in the US^[84] and almost all in the UK^[85][86][87] receive bilateral ECT.

The electrodes deliver an electrical stimulus. The stimulus levels recommended for ECT are in excess of an individual's seizure threshold: about one and a half times seizure threshold for bilateral ECT and up to 12 times for unilateral ECT.

ECT is usually administered three times a week, on alternate days, over a course of two to four weeks.[1]^{: 1882–1883}

Neuroimaging prior to ECT

Neuroimaging prior to ECT may be useful for detecting intracranial pressure or mass given that patients respond less when one of these conditions exist. Nonetheless, it is not indicated due to high cost and low prevalence of these conditions in patients needing ECT.^[95]

Concurrent pharmacotherapy

Whether psychiatric medications are terminated prior to treatment or maintained, varies.

A 2009 RCT provides some evidence indicating that concurrent use of some antidepressant improves ECT efficacy.[37]

Course

ECT is usually done from 6 to 12 times in 2 to 4 weeks but can sometimes exceed 12 rounds.^[37] It is also recommended to not do ECT more than 3 times per week.^[37]

Treatment team

In the US, the medical team performing the procedure typically consists of a psychiatrist, an anesthetist, an ECT treatment nurse or qualified assistant, and one or more recovery nurses.^[5]: 109 Medical trainees may assist, but only under the direct supervision of credentialed attending physicians and staff.^[5]: 110

Devices

Most modern ECT devices deliver a brief-pulse current, which is thought to cause fewer cognitive effects than the sine-wave currents which were originally used in ECT.^[1] A small minority of psychiatrists in the US still use sine-wave stimuli.^[84] Sine-wave is no longer used in the UK or Ireland.^[87] Typically, the electrical stimulus used in ECT is about 800

In the US, ECT devices are manufactured by two companies, Somatics, which is owned by psychiatrists Richard Abrams and Conrad Swartz, and Mecta.[98] In the UK, the market for ECT devices was long monopolized by Ectron Ltd, which was set up by psychiatrist Robert Russell.^[99]

Mechanism of action

Despite decades of research, the exact mechanism of action of ECT remains elusive. A review from 2022 of neuroimaging studies based on a global data collaboration resulted in a model of temporary disruption of neural circuits followed by augmented neuroplasticity and rewiring.^[32]

Use

As of 2001, it was estimated that about one million people received ECT annually.^[26]

There is wide variation in ECT use between different countries, different hospitals, and different psychiatrists.^[1][26] International practice varies considerably from widespread use of the therapy in many Western countries to a small minority of countries that do not use ECT at all, such as Slovenia.^[100]

About 70 percent of ECT patients are women.^[1] This may be because women are more likely to be diagnosed with depression.^[1][101] Older and more affluent patients are also more likely to receive ECT. The use of ECT is not as common in ethnic minorities.^[101][102]

In Sweden, which has a complete register of all ECT treatments in the country, in 2013 the rate of persons treated in that year per 100,000 inhabitants was 41. Almost the same rate had already been present in 1975 with 42 patients per 100,000 inhabitants.^[103][104]

United States

ECT became popular in the US in the 1940s. At the time, psychiatric hospitals were overrun with patients whom doctors were desperate to treat and cure. Whereas

Accurate statistics about the frequency, context and circumstances of ECT in the US are difficult to obtain because only a few states have reporting laws that require the treating facility to supply state authorities with this information.[106] In 13 of the 50 states, the practice of ECT is regulated by law.^[107]

In the mid-1990s in Texas, ECT was used in about one third of psychiatric facilities and given to about 1,650 people annually.^[101] Usage of ECT has since declined slightly; in 2000–01 ECT was given to about 1,500 people aged from 16 to 97 (in Texas it is illegal to give ECT to anyone under sixteen).^[108] ECT is more commonly used in private psychiatric hospitals than in public hospitals, and minority patients are underrepresented in the ECT statistics.^[1]

In the United States, ECT is usually given three times a week; in the United Kingdom, it is usually given twice a week.^[1] Occasionally it is given on a daily basis.^[1] A course usually consists of 6–12 treatments, but may be more or fewer. Following a course of ECT some patients may be given continuation or maintenance ECT with further treatments at weekly, fortnightly or monthly intervals.^[1] A few psychiatrists in the US use multiple-monitored ECT (MMECT), where patients receive more than one treatment per anesthetic.^[1] Electroconvulsive therapy is not a required subject in US medical schools and not a required skill in psychiatric residency training. Privileging for ECT practice at institutions is a local option: no national certification standards are established, and no ECT-specific continuing training experiences are required of ECT practitioners.^[109]

United Kingdom

In the UK in 1980, an estimated 50,000 people received ECT annually, with use declining steadily since then^[110] to about 12,000 per annum in 2002.^[111] It is still used in nearly all psychiatric hospitals, with a survey of ECT use from 2002 finding that 71 percent of patients were women and 46 percent were over 65 years of age. Eighty-one percent had a diagnosis of mood disorder; schizophrenia was the next most common diagnosis. Sixteen percent were treated without their consent.^[111] In 2003, the National Institute for Health and Care Excellence, a government body which was set up to standardize treatment throughout the National Health Service in England and Wales, issued guidance on the use of ECT. Its use was recommended "only to achieve rapid and short-term improvement of severe symptoms after an adequate trial of treatment options has proven ineffective and/or when the condition is considered to be potentially life-threatening in individuals with severe depressive illness, catatonia or a prolonged manic episode".^[112]

The guidance received a mixed reception. It was welcomed by an editorial in the British Medical Journal^[113] but the Royal College of Psychiatrists launched an unsuccessful appeal.^[114] The NICE guidance, as the British Medical Journal editorial points out, is only a policy statement and psychiatrists may deviate from it if they see fit. Adherence to standards has not been universal in the past. A survey of ECT use in 1980 found that more than half of ECT clinics failed to meet minimum standards set by the Royal College of Psychiatrists, with a later survey in 1998 finding that minimum standards were largely adhered to, but that two-thirds of clinics still fell short of current guidelines, particularly in the training and supervision of junior doctors involved in the procedure.^[115] A voluntary accreditation scheme, ECTAS, was set up in 2004 by the Royal College, and as of 2017^[update] the vast majority of ECT clinics in England, Wales, Northern Ireland and the Republic of Ireland have signed up.^[116]

The Mental Health Act 2007 allows people to be treated against their will. This law has extra protections regarding ECT. A patient capable of making the decision can decline the treatment, and in that case treatment cannot be given unless it will save that patient's life or is immediately necessary to prevent deterioration of the patient's condition. A patient may not be capable of making the decision (they "lack capacity"), and in that situation ECT can be given if it is appropriate and also if there are no advance directives that prevent the use of ECT.^[117]

China

ECT was introduced in China in the early 1950s and while it was originally practiced without anesthesia, as of 2012 almost all procedures were conducted with it. As of 2012, there are approximately 400 ECT machines in China, and 150,000 ECT treatments are performed each year.^[118] Chinese national practice guidelines recommend ECT for the treatment of schizophrenia, depressive disorders, and bipolar disorder and in the Chinese literature, ECT is an effective treatment for schizophrenia and mood disorders.^[118]

Although the Chinese government stopped classifying homosexuality as an illness in 2001, electroconvulsive therapy is still used by some establishments as a form of "conversion therapy".^[119][120] Alleged Internet addiction (or general unruliness) in adolescents is also known to have been treated with ECT, sometimes without anestheia, most notably by Yang Yongxin. The practice was banned in 2009 after news on Yang broke out.^[121]

Society and culture

Controversy

Surveys of public opinion, the testimony of former patients, legal restrictions on the use of ECT and disputes as to the efficacy, ethics and adverse effects of ECT within the psychiatric and wider medical community indicate that the use of ECT remains controversial.^{[122][123][124][125][126][127][128]} This is reflected in the January 2011 vote by the FDA's Neurological Devices Advisory Panel to recommend that FDA maintain ECT devices in the Class III device category for high risk devices, except for patients with catatonia, major depressive disorder, and bipolar disorder.^[129] This may result in the manufacturers of such devices having to do controlled trials on their safety and efficacy for the first time.^{[4][130][131]} In justifying their position, panelists referred to the memory loss associated with ECT and the lack of long-term data.^[132]

Legal status

Informed consent

The World Health Organization (2005) advises that ECT should be used only with the informed consent of the patient (or their guardian if their incapacity to consent has been established).^[34]

In the US, this doctrine places a legal obligation on a doctor to make a patient aware of the reason for treatment, the risks and benefits of a proposed treatment, the risks and benefits of alternative treatment, and the risks and benefits of receiving no treatment. The patient is then given the opportunity to accept or reject the treatment. The form states how many treatments are recommended and also makes the patient aware that consent may be revoked and treatment discontinued at any time during a course of ECT.^[3] The US Surgeon General's Report on Mental Health states that patients should be warned that the benefits of ECT are short-lived without active continuation treatment in the form of drugs or further ECT, and that there may be some risk of permanent, severe memory loss after ECT.^[3] The report advises psychiatrists to involve patients in discussion, possibly with the aid of leaflets or videos, both before and during a course of ECT.

According to the US Surgeon General, involuntary treatment is uncommon in the US and is typically used only in cases of great extremity, and only when all other treatment options have been exhausted. The use of ECT is believed to be a potentially life-saving treatment.^[74]

In one of the few jurisdictions where recent statistics on ECT usage are available, a national audit of ECT by the Scottish ECT Accreditation Network indicated that 77% of patients who received the treatment in 2008 were capable of giving informed consent.^[133]

In the UK, in order for consent to be valid it requires an explanation in "broad terms" of the nature of the procedure and its likely effects.^[134] One review from 2005 found that only about half of patients felt they were given sufficient information about ECT and its adverse effects^[135] and another survey found that about fifty percent of psychiatrists and nurses agreed with them.^[136]

A 2005 study published in the British Journal of Psychiatry described patients' perspectives on the adequacy of informed consent before ECT.^[135] The study found that "About half (45–55%) of patients reported they were given an adequate explanation of ECT, implying a similar percentage felt they were not." The authors also stated:

Approximately a third did not feel they had freely consented to ECT even when they had signed a consent form. The proportion who feel they did not freely choose the treatment has actually increased over time. The same themes arise whether the patient had received treatment a year ago or 30 years ago. Neither current nor proposed safeguards for patients are sufficient to ensure informed consent with respect to ECT, at least in England and Wales.^[135]

Involuntary ECT

Procedures for involuntary ECT vary from country to country depending on local mental health laws.

United States

In most states in the US, a judicial order following a formal hearing is needed before a patient can be forced to undergo involuntary ECT.^[3] However, ECT can also be involuntarily administered in situations with less immediate danger. Suicidal intent is a common justification for its involuntary use, especially when other treatments are ineffective.^[3]

United Kingdom

Until 2007 in England and Wales, the

In Western Australia, ECT has been heavily restricted since 2014, after a bill passed with bipartisan support introducing restrictions on ECT, which were welcomed by mental health experts. Children under 14 are prohibited from receiving ECT, while those aged 14 to 18 must have informed consent approval from the Mental Health Tribunal. The law imposes a $15,000 fine on anyone who performs ECT on a child under the age of 14.^[144]

Similarly, ECT is also banned on children under the age of 12 in the Australian Capital Territory (ACT).^[145]

United States

Many mental health facilities offer ECT for specific diagnoses, such as

In 2020 the Food and Drug Administration (FDA) implemented a rule previously drafted in 2016 banning the use of ECT to treat disabilities. This ban specifically had major complications for the controversial Judge Rotenberg Center (JRC) in Canton, Massachusetts, which uses various methods of ECT. Specifically, it is believed by many that most of the cases at JRC do not require the use of ECT.^{[148][149][150]}

Public perception

A questionnaire survey of 379 members of the general public in

• Ernest Hemingway, an American author, died by suicide in 1961 half a year after ECT treatment at the Mayo Clinic in 1960.^[152] He is reported to have said to his biographer, "Well, what is the sense of ruining my head and erasing my memory, which is my capital, and putting me out of business? It was a brilliant cure but we lost the patient."^[153] However, the same biographer (Hotchner, 1966) and also a second biographer (Lynn, 1987) emphasized - according to a review from 2008 - "that Hemingway’s serious mental illness and plans for suicide significantly predated his ECT treatments."^[154]

• Robert Pirsig had a nervous breakdown and spent time in and out of psychiatric hospitals between 1961 and 1963.^[155] He was diagnosed with paranoid schizophrenia and clinical depression as a result of an evaluation conducted by psychoanalysts, and was treated with electroconvulsive therapy on numerous occasions,^[156] a treatment he discusses in his novel, Zen and the Art of Motorcycle Maintenance.^[157]

• 1972 United States Presidential Election as the party's vice presidential candidate after it was revealed that he had received electroshock treatment in the past for depression.^[158] Presidential nominee George McGovern replaced him with Sargent Shriver, and later went on to lose by a landslide to Richard Nixon
  .
• American surgeon and award-winning author Sherwin B. Nuland is another notable person who has undergone ECT.^[159] In his 40s, his depression became so severe that he had to be institutionalized. After exhausting all treatment options, a young resident assigned to his case suggested ECT, which ended up being successful.^[160]
• Author David Foster Wallace also received ECT for many years, beginning as a teenager, before his suicide at age 46.^[161]
• New Zealand author Janet Frame experienced both insulin coma therapy and ECT (but without the use of anesthesia or muscle relaxants).^[162] She wrote about this in her autobiography, An Angel at My Table (1984),^[162] which was later adapted into a film (1990).^[163]
• American actor Carrie Fisher wrote about her experience with memory loss after ECT treatments in her memoir Wishful Drinking.^[164]
• Lou Reed had ECT as a teenager to "cure" his homosexuality.^[165] He later claimed it had induced multiple personality disorder, and resulted in his hatred of psychiatrists.^[166] After Reed's death, his sister denied the ECT treatments were intended to suppress his "homosexual urges", asserting that their parents were not homophobic but had been told by his doctors that ECT was necessary to treat Reed's mental and behavioral issues.^[165]

Fictional examples

Electroconvulsive therapy has been depicted in fiction, including fictional works partly based on true experiences. These include Sylvia Plath's semi-autobiographical novel, The Bell Jar, Ken Loach's film Family Life, and Ken Kesey's novel One Flew Over the Cuckoo's Nest; Kesey's novel is a direct product of his time working the graveyard shift as an orderly at a mental health facility in Menlo Park, California.^[167][168]

Two analyses of large numbers of films using ECT scenes found that almost all presented fictional settings that were unrelated to real treatment routines and were apparently aimed at stigmatizing ECT as a tool of repression and of mind and behavior control - having effects of memory-erosion, pain and damage.^[169][170]

The song “The Mind Electric” by

• Neurostimulation
• Psychosurgery
• Transcranial magnetic stimulation
• Magnetic seizure therapy

References

External links

Wikimedia Commons has media related to Electroconvulsive therapy.

• Position Statement on Electroconvulsive Therapy (ECT) 2015 – from the American Psychiatric Association.
• ECT – information from mental health charity The Royal College of Psychiatrists