Enadoline

Enadoline

Clinical data
ATC code	none
Identifiers
IUPAC name 2-(1-Benzofuran-4-yl)-N-methyl-N-[(5R,7S,8S)-7-pyrrolidin-1-yl-1-oxaspiro[4.5]decan-8-yl]acetamide
JSmol)	Interactive image
SMILES O=C(Cc1cccc2occc12)N(C)C1CCC2(CCCO2)CC1N1CCCC1
InChI InChI=1S/C24H32N2O3/c1-25(23(27)16-18-6-4-7-22-19(18)9-15-28-22)20-8-11-24(10-5-14-29-24)17-21(20)26-12-2-3-13-26/h4,6-7,9,15,20-21H,2-3,5,8,10-14,16-17H2,1H3/t20-,21-,24-/m0/s1 Y Key:JMBYBVLCYODBJQ-HFMPRLQTSA-N Y
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Enadoline is a drug which acts as a highly selective

In human studies, it produced visual distortions and feelings of dissociation, reminiscent of the effects of salvinorin A.^[1]

It was studied as a potential analgesic, but abandoned because of the dose-limiting effects of dysphoria, which could be expected from a κ-opioid agonist. There was mention of its potential in treating comatose head injury or stroke victims, where that type of side effect would be immaterial.^[2]

Potency

When enadoline was first reported in 1990, it was "the most potent κ-selective analgesic ever reported ... 25 times more potent than morphine and 17 times more potent than

• U-69,593
• U-50,488
• U-77891
• AH-7921
• bromadoline

References

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