Endothelin receptor antagonist
An endothelin receptor antagonist (ERA) is a drug that blocks endothelin receptors.
Three main kinds of ERAs exist:
- selective ETA receptor antagonists (endothelin A receptors.
- dual antagonists (bosentan, macitentan, tezosentan), which affect both endothelin A and B receptors.[1]
- selective ETB receptor antagonists (BQ-788 and A192621) which affect endothelin B receptors are used in research but have not yet reached the clinical trial stage.
pulmonary arterial hypertension, while atrasentan is an experimental anti-cancer
drug.
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