Endothelium-derived relaxing factor
This article needs to be updated.(January 2022) |
The Endothelium-derived relaxing factor (EDRF) is a strong
Physiological Functions and production
EDRF serves various functions, of which the most common and topical are vasodilation and the prevention of
EDRF is produced from
EDRF then diffuses to the smooth muscle in vascular tissue (vessels may be large or small), here it enacts
The NO compound is also capable of reducing clotting in the blood stream due to its ability to prevent platelet adhesion and aggregation.[4]
Related pathology
Atherosclerosis and hypertension are grave contributors in the group of pathological conditions under the umbrella of Cardiovascular disease. Among these conditions is also the disfunction of the endothelium, which given its properties of vasodilation when functional, can cause excessive vasoconstriction, thus leading back to hypertension. Another effect of this particular disfunction may also be excessive platelet adhesion, signifying a significant increase in blood clots, thus the promotion of a prothrombotic state.[4]
References
- ^ "Endothelium Derived Relaxing Factor - an overview | ScienceDirect Topics". www.sciencedirect.com. Retrieved 2023-01-21.
- PMID 21156995.
- PMID 20716671.
- ^ PMID 30725695, retrieved 2023-01-21
External links
- Pirahanchi, Yasaman; Marsidi, Jennifer L.; Brown, Kristen N. (2022), "Physiology, Endothelial Derived Relaxation Factor", StatPearls, Treasure Island (FL): StatPearls Publishing, PMID 30725695, retrieved 2022-01-29
- Ignarro, L. J.; Buga, G. M.; Wood, K. S.; Byrns, R. E.; Chaudhuri, G. (1987-12-01). "Endothelium-derived relaxing factor produced and released from artery and vein is nitric oxide". Proceedings of the National Academy of Sciences. 84 (24): 9265–9269. PMID 2827174.
- Vanhoutte, P.-M.; Boulanger, C.-M.; Mombouli, J.-V. (1995-11-24). "Endothelium-derived relaxing factors and converting enzyme inhibition". American Journal of Cardiology. 76 (15): 3E–12E. PMID 7484885.