Toxin

Source: Wikipedia, the free encyclopedia.
(Redirected from
Environmental toxins
)

The Amanita muscaria mushroom, an iconic toxic mushroom.

A toxin is a

toxic
".

Toxins can be

body tissues interacting with biological macromolecules such as enzymes or cellular receptors. They vary greatly in their toxicity, ranging from usually minor (such as a bee sting) to potentially fatal even at extremely low doses (such as botulinum toxin).[5][6]

Terminology

Toxins are often distinguished from other chemical agents strictly based on their biological origin.[7]

Less strict understandings embrace naturally occurring

inorganic
poisons. It is important to confirm usage if a common understanding is critical.

Toxins are a subset of toxicants. The term toxicant is preferred when the poison is man-made and therefore artificial.[14] The human and scientific genetic assembly of a natural-based toxin should be considered a toxin as it is identical to its natural counterpart.[15] The debate is one of linguistic semantics.

The word toxin does not specify method of delivery (as opposed to venom, a toxin delivered via a bite, sting, etc.). Poison is a related but broader term that encompasses both toxins and toxicants; poisons may enter the body through any means - typically inhalation, ingestion, or skin absorption. Toxin, toxicant, and poison are often used interchangeably despite these subtle differences in definition. The term toxungen has also been proposed to refer to toxins that are delivered onto the body surface of another organism without an accompanying wound.[16]

A rather informal terminology of individual toxins relates them to the anatomical location where their effects are most notable:

On a broader scale, toxins may be classified as either

endotoxins, which are released mainly when bacteria are lysed
.

Biological

The term "biotoxin" is sometimes used to explicitly confirm the biological origin as opposed to environmental or anthropogenic origins.[17][18] Biotoxins can be classified by their mechanism of delivery as poisons (passively transferred via ingestion, inhalation, or absorption across the skin), toxungens (actively transferred to the target's surface by spitting, spraying, or smearing), or venoms (delivered through a wound generated by a bite, sting, or other such action).[16] They can also be classified by their source, such as fungal biotoxins, microbial toxins, plant biotoxins, or animal biotoxins.[19][20]

Toxins produced by

pathogenicity and/or evasion of the host immune response.[21]

Biotoxins vary greatly in purpose and mechanism, and can be highly complex (the venom of the cone snail can contain over 100 unique peptides, which target specific nerve channels or receptors).[22]

Biotoxins in nature have two primary functions:

Some of the more well known types of biotoxins include:

Weaponry

Many living organisms employ toxins offensively or defensively. A relatively small number of toxins are known to have the potential to cause widespread sickness or casualties. They are often inexpensive and easily available, and in some cases it is possible to refine them outside the laboratory.[24] As biotoxins act quickly, and are highly toxic even at low doses, they can be more efficient than chemical agents.[24] Due to these factors, it is vital to raise awareness of the clinical symptoms of biotoxin poisoning, and to develop effective countermeasures including rapid investigation, response, and treatment.[19][25][24]

Environmental

The term "environmental toxin" can sometimes explicitly include synthetic contaminants[26] such as industrial pollutants and other artificially made toxic substances. As this contradicts most formal definitions of the term "toxin", it is important to confirm what the researcher means when encountering the term outside of microbiological contexts.

Environmental toxins from food chains that may be dangerous to human health include:

Research

In general, when scientists determine the amount of a substance that may be hazardous for humans, animals and/or the environment they determine the amount of the substance likely to trigger effects and if possible establish a safe level. In Europe, the European Food Safety Authority produced risk assessments for more than 4,000 substances in over 1,600 scientific opinions and they provide open access summaries of human health, animal health and ecological hazard assessments in their OpenFoodTox[37] database.[38][39] The OpenFoodTox database can be used to screen potential new foods for toxicity.[40]

The Toxicology and Environmental Health Information Program (TEHIP)[41] at the United States National Library of Medicine (NLM) maintains a comprehensive toxicology and environmental health web site that includes access to toxins-related resources produced by TEHIP and by other government agencies and organizations.[42] This web site includes links to databases, bibliographies, tutorials, and other scientific and consumer-oriented resources. TEHIP also is responsible for the Toxicology Data Network (TOXNET),[43] an integrated system of toxicology and environmental health databases that are available free of charge on the web.

Superfund Basic Research Programs
.

See also

References

  1. ^ Harper, Douglas. "toxin". Online Etymology Dictionary.
  2. ^ "toxin – Definition from the Merriam-Webster Online Dictionary". Retrieved 13 December 2008.
  3. ^ "toxin" at Dorland's Medical Dictionary
  4. OCLC 41299257
    .
  5. .
  6. ^ "Diagnosis and Treatment | Botulism". CDC. 1 June 2021. Archived from the original on 12 April 2022. Retrieved 12 April 2022.
  7. PMID 26402705
    .
  8. ^ Goodman, Brenda. "Arsenic in Food: FAQ". WebMD. Retrieved 20 May 2022.
  9. ^ "Arsenic in your food - Our findings show a real need for federal standards for this toxin". Consumer Reports. 2012.
  10. S2CID 236989837
    .
  11. ^ "U.S. Code". Retrieved 20 May 2022. the term "toxin" means the toxic material or product of plants, animals, microorganisms ...or a recombinant or synthesized molecule...
  12. ^ "Module 1: Introduction to Toxicology" (PDF). Agency for Toxic Substances and Disease Registry. Retrieved 20 May 2022. arsenic, a toxic metal, may occur as a natural contaminant ... or ... as a by-product of industrial activities. If the second case is true, such toxic substances are referred to as toxicants, rather than toxins.
  13. ^ Goldblat, Jozef (30 June 1997). "The Biological Weapons Convention – An overview". Retrieved 20 May 2022. The Convention applies to all natural or artificially created toxins, "whatever their origin or method of production" (Article I). It thus covers toxins produced biologically, as well as those produced by chemical synthesis
  14. ^ "Difference Between Toxin and Toxicant (With Table)". 31 October 2021.
  15. PMID 2847744
    .
  16. ^ .
  17. ^ "biotoxin – Definition from the Merriam-Webster Online Dictionary". Retrieved 13 December 2008.
  18. ^ "biotoxin" at Dorland's Medical Dictionary
  19. ^ a b Editorial, Team (24 May 2021). "Toxins: Venom within Living Cells or Organisms". Unrevealed Files. Retrieved 17 July 2021.
  20. ^ "Biotoxins: What are Biotoxins?". www.biosciences-labs.bham.ac.uk. Retrieved 6 July 2023.
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  37. ^ "Chemical hazards data - OpenFoodTox". European Food Safety Authority. Retrieved 27 October 2019.
  38. PMID 32625280
    .
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  41. ^ "Environmental Health and Toxicology Information". National Library of Medicine. Archived from the original on 1 September 2018. Retrieved 29 September 2010.
  42. S2CID 34029729
    .
  43. ^ "TOXNET". toxnet.nlm.nih.gov. Archived from the original on 14 May 2019. Retrieved 29 September 2010.
  44. PMID 16893844
    .

External links