Ephrin A5

Source: Wikipedia, the free encyclopedia.
EFNA5
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_001962

NM_010109
NM_207654

RefSeq (protein)

NP_001953

NP_034239
NP_997537

Location (UCSC)Chr 5: 107.38 – 107.67 MbChr 17: 62.91 – 63.19 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Ephrin A5 is a protein that in humans is encoded by the EFNA5 gene.[5][6][7]

Ephrin A5 is a

EphB2 receptor.[8]

Reverse signaling in growth cone survival

"Reverse" signaling is one unique property of ephrin ligands that allows for the transmission of an intracellular signal in ephrin-expressing cells that is distinct from the signal transmitted in Eph receptor-expressing cells. Although the mechanism of "reverse" signaling by ephrin-As is not well understood, it is relatively surprising considering that ephrin-A ligands are attached to the cell membrane solely by a GPI linkage and unlike ephrin-Bs, lack a potential intracellular signaling domain. Nonetheless, certain ephrin-A ligands are known to initiate reverse signaling cascades like ephrin A5, which has been shown to stimulate the spreading of growth cones in cultures of mouse spinal motor neurons.[9] Reverse signaling by ephrin A5 was demonstrated to be GPI-dependent as the elimination of all GPI linkages by the application of a phosphatidlyinositol-specific phospholipase C abolished the positive effects of ephrin A5 on growth cone spreading. Additionally, EphA receptors were shown to exert opposite effects on motor neuron growth cones by reducing growth cone size.

Formation of the retinotopic map

This finding that ephrin A5 promotes growth cone survival that is opposite of EphA signaling and mediated directly by ephrin A5 reverse signaling has important implications for

anterior SC.[10]

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000184349 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000048915 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 8661153
    .
  6. .
  7. ^ "Entrez Gene: EFNA5 ephrin-A5".
  8. S2CID 15643420
    .
  9. ^ .
  10. .

Further reading

External links