Epiboxidine

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Epiboxidine
Legal status
Legal status
  • Investigational
Identifiers
  • (1R,4S,6S)-6-(3-Methylisoxazol-5-yl)-7-azabicyclo[2.2.1]heptane
JSmol)
  • CC1=NOC(=C1)[C@H]2C[C@@H]3CC[C@H]2N3
  • InChI=1S/C10H14N2O/c1-6-4-10(13-12-6)8-5-7-2-3-9(8)11-7/h4,7-9,11H,2-3,5H2,1H3/t7-,8-,9+/m0/s1
  • Key:GEEFPQBPVBFCSD-XHNCKOQMSA-N

Epiboxidine is a chemical compound which acts as a

side effects
.

Epiboxidine is around one-tenth as potent as epibatidine as an α4β2 agonist, but has around the same potency as an α3β4 agonist. It has only one-tenth of the analgesic power of epibatidine, but is also much less toxic.[1][2][3]

Uses

Despite its decreased potency and toxicity compared to epibatidine, epiboxidine itself is still too toxic to be developed as a drug for use in humans. It is used in scientific research[4] and as a parent compound to derive newer analogues which may be safer and have greater potential for clinical development.[5][6][7]

See also

References

  1. PMID 18644719
    .
  2. PMID 22566097
    .
  3. PMID 9063687
    .
  4. S2CID 25993659
    .
  5. PMID 14697783
    .
  6. PMID 15026069
    .
  7. PMID 17867705
    .
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