Epstein–Barr virus nuclear antigen 3
| Epstein–Barr virus nuclear antigen 3 | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| Symbol | EBV-NA3 | ||||||||
SCOP2 | 1m05 / SCOPe / SUPFAM | ||||||||
| |||||||||
The Epstein–Barr virus nuclear antigen 3 (EBNA-3) is a family of viral proteins associated with the Epstein–Barr virus. A typical EBV genome contains three such proteins:[1]
- EBNA-3A (P12977, EBNA-3; BLRF3-BERF1)
- EBNA-3B (P03203, EBNA-4; BERF2A-BERF2B)
- EBNA-3C (P03204, EBNA-6, EBNA-4B; BERF3-BERF4)
These genes also bind the host RBP-Jκ protein.[2]
EBNA-3C can recruit a ubiquitin ligase and has been shown to target cell-cycle regulators such as retinoblastoma protein (pRb).[3][4]
References
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