Ergometrine

Source: Wikipedia, the free encyclopedia.
Ergometrine
Clinical data
Trade namesErgometrine Maleate, Ergonovine Maleate, Ergotrate, Ergotrate Maleate, Ergostat, Syntometrine, others[1][2]
Other namesErgonovine; d-Lysergic acid β-propanolamide
AHFS/Drugs.comMonograph
Pregnancy
category
  • X
Routes of
administration
By mouth
ATC code
Legal status
Legal status
Biliary
Identifiers
  • (6aR,9R)-N-((S)-1-Hydroxypropan- 2-yl)-7-methyl-4,6,6a,7,8,9-hexahydroindolo[4,3-fg]quinoline-9-carboxamide
JSmol)
  • [H][C@@]12Cc3c[nH]c4cccc(C1=C[C@@H](C(=O)N[C@@H](C)CO)CN2C)c34
  • InChI=1S/C19H23N3O2/c1-11(10-23)21-19(24)13-6-15-14-4-3-5-16-18(14)12(8-20-16)7-17(15)22(2)9-13/h3-6,8,11,13,17,20,23H,7,9-10H2,1-2H3,(H,21,24)/t11-,13+,17+/m0/s1 checkY
  • Key:WVVSZNPYNCNODU-XTQGRXLLSA-N checkY
  (verify)

Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause contractions of the

injection into a vein.[4] It begins working within 15 minutes when taken by mouth and is faster in onset when used by injection.[4] Effects last between 45 and 180 minutes.[4]

Common side effect include

Ergometrine was discovered in 1932.[5] It is on the World Health Organization's List of Essential Medicines.[8][9]

Medical uses

Ergometrine has a medical use in

syntometrine
.

It can induce spasm of the

variant (Prinzmetal's) angina.[11]

Side effects

Possible side effects include

rashes, and shock.[12] An overdose produces a characteristic poisoning, ergotism or "St. Anthony's fire": prolonged vasospasm resulting in gangrene
and amputations; hallucinations and dementia; and abortions.

Gastrointestinal disturbances such as diarrhea, nausea, and vomiting, are common.[13] The drug is contraindicated in pregnancy, vascular disease, and psychosis.

Pharmacology

Pharmacodynamics

While ergometrine acts at

smooth muscles) a powerful stimulant effect not clearly associated with a specific receptor type.[citation needed
]

Ergometrine produces

History

The pharmacological properties of ergot were known and had been utilised by midwives for centuries, but were not thoroughly researched and publicized until the early 20th century. However, its abortifacient effects and the danger of ergotism meant that it was only prescribed cautiously, as in the treatment of

Ergometrine was first isolated and obtained by the chemists

maternal mortality rate in much of the West during the early 20th century.[17]

Society and culture

Legal status

Ergometrine is listed as Table I precursors under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, as possible precursor compound for LSD.[20] As an N-alkyl derivative of lysergamide, ergometrine is also covered by the Misuse of Drugs Act 1971, effectively rendering it illegal in the United Kingdom.

References

  1. ^ .
  2. .
  3. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-15.
  4. ^ a b c d e f "Ergonovine Maleate". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-25. Retrieved 1 December 2015.
  5. ^ from the original on 2015-12-26.
  6. from the original on 2015-12-26.
  7. from the original on 2015-12-26.
  8. . WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
  9. . WHO/MHP/HPS/EML/2021.02.
  10. .
  11. .
  12. ^ "Ergometrine drug information". DrugsUpdate.com. Archived from the original on 2012-04-25.
  13. PMID 14973949
    .
  14. .
  15. .
  16. .
  17. ^ .
  18. .
  19. .
  20. ^ "List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances Under International Control" (PDF) (Eleventh ed.). Vienna, Austria: International Narcotics Control Board. January 2007. Archived from the original (PDF) on February 27, 2008.

External links

  • "Ergotrate". Drug Information Portal. U.S. National Library of Medicine. 15 November 2018.