Ergometrine
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Trade names | Ergometrine Maleate, Ergonovine Maleate, Ergotrate, Ergotrate Maleate, Ergostat, Syntometrine, others[1][2] |
Other names | Ergonovine; d-Lysergic acid β-propanolamide |
AHFS/Drugs.com | Monograph |
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Routes of administration | By mouth |
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Ergometrine, also known as ergonovine and sold under the brand names Ergotrate, Ergostat, and Syntometrine among others, is a medication used to cause contractions of the
Common side effect include
Ergometrine was discovered in 1932.[5] It is on the World Health Organization's List of Essential Medicines.[8][9]
Medical uses
Ergometrine has a medical use in
It can induce spasm of the
Side effects
Possible side effects include
Gastrointestinal disturbances such as diarrhea, nausea, and vomiting, are common.[13] The drug is contraindicated in pregnancy, vascular disease, and psychosis.
Pharmacology
Pharmacodynamics
While ergometrine acts at
Ergometrine produces
History
The pharmacological properties of ergot were known and had been utilised by midwives for centuries, but were not thoroughly researched and publicized until the early 20th century. However, its abortifacient effects and the danger of ergotism meant that it was only prescribed cautiously, as in the treatment of
Ergometrine was first isolated and obtained by the chemists
Society and culture
Legal status
Ergometrine is listed as Table I precursors under the United Nations Convention Against Illicit Traffic in Narcotic Drugs and Psychotropic Substances, as possible precursor compound for LSD.[20] As an N-alkyl derivative of lysergamide, ergometrine is also covered by the Misuse of Drugs Act 1971, effectively rendering it illegal in the United Kingdom.
References
- ^ ISBN 978-0-7514-0499-9.
- ISBN 978-3-88763-075-1.
- ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-15.
- ^ a b c d e f "Ergonovine Maleate". The American Society of Health-System Pharmacists. Archived from the original on 2015-12-25. Retrieved 1 December 2015.
- ^ ISBN 9783527326693. Archivedfrom the original on 2015-12-26.
- ISBN 9780471899792. Archivedfrom the original on 2015-12-26.
- ISBN 9780854041787. Archivedfrom the original on 2015-12-26.
- hdl:10665/325771. WHO/MVP/EMP/IAU/2019.06. License: CC BY-NC-SA 3.0 IGO.
- hdl:10665/345533. WHO/MHP/HPS/EML/2021.02.
- PMID 16162623.
- PMID 10987346.
- ^ "Ergometrine drug information". DrugsUpdate.com. Archived from the original on 2012-04-25.
- PMID 14973949.
- PMID 7420432.
- S2CID 241134396.
- PMID 24361689.
- ^ S2CID 53277037.
- PMID 20778930.
- S2CID 221118172.
- ^ "List of Precursors and Chemicals Frequently Used in the Illicit Manufacture of Narcotic Drugs and Psychotropic Substances Under International Control" (PDF) (Eleventh ed.). Vienna, Austria: International Narcotics Control Board. January 2007. Archived from the original (PDF) on February 27, 2008.
External links
- "Ergotrate". Drug Information Portal. U.S. National Library of Medicine. 15 November 2018.