Ethacridine lactate

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Ethacridine lactate
Skeletal formulas of ethacridine lactate
Ball-and-stick models of the component ions of ethacridine lactate
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 7-Ethoxyacridine-3,9-diamine 2-hydroxypropanoic acid
JSmol)
  • O=C(O)C(O)C.O(c2ccc1nc3c(c(c1c2)N)ccc(c3)N)CC
  • InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6) checkY
  • Key:IYLLULUTZPKQBW-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ethacridine lactate (ethacridine monolactate monohydrate, acrinol,

aromatic organic compound based on acridine
. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Its primary use is as an

Staphylococci, but ineffective against Gram-negative bacteria such as Pseudomonas aeruginosa.[2]

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used.[3] Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.

References

  1. ^ Merck Index, 11th Ed., 3668
  2. PMID 2517004
    .
  3. PMID 6843933
    .
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