Ethocybin

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Ethocybin
Skeletal formula of ethocybin
Ball-and-stick model of the ethocybin molecule as a zwitterion
Clinical data
Other names4-Phosphoryloxy-N,N-diethyltryptamine; CEY-39; 4-phosphoryloxy-DET; 4-PO-DET
ATC code
  • none
Legal status
Legal status
Identifiers
  • Phosphoric acid mono-[3-(2-diethylamino-ethyl)-1H-indol-4-yl] ester
JSmol)
  • CCN(CC)CCC2=CNC1=CC=CC(OP(O)(O)=O)=C12
  • InChI=1S/C14H21N2O4P/c1-3-16(4-2)9-8-11-10-15-12-6-5-7-13(14(11)12)20-21(17,18)19/h5-7,10,15H,3-4,8-9H2,1-2H3,(H2,17,18,19) checkY
  • Key:AAVKQQUBPHSCML-UHFFFAOYSA-N checkY
  (verify)

Ethocybin (CEY-19; 4-phosphoryloxy-DET; 4-PO-DET) is a

semi-synthetic psychedelic alkaloid of the tryptamine family. Effects of ethocybin are comparable to those of a shorter LSD or psilocybin trip, although intensity and duration vary depending on dosage, individual physiology, and set and setting.[1][2]

Chemistry

As with psilocybin, miprocybin and metocybin, ethocybin is a

in the body.

Albert Hofmann was the first to produce this chemical, soon after his discovery of psilocin and psilocybin.[4] It was sold under the code name CEY-39.

Pharmacology

As with psilocybin, ethocybin is rapidly dephosphorylated in the body to

serotonin receptor in the brain where it mimics the effects of serotonin (5-HT).[5]

Medicine

Ethocybin has been studied as a treatment for several disorders since the early 1960s, and numerous papers are devoted to this material.[citation needed] Its short-lived action was considered a virtue. A 2010 Study showed that Ethocybin helped with bipolar affective disorder.

Effects

Ethocybin is absorbed through the lining of the mouth and stomach. Effects begin 20–45 minutes after ingestion, and last from 2–4 hours depending on dose, species, and individual metabolism.[citation needed] The effects are somewhat shorter compared to psilocybin.

Pharmacology

Ethocybin is probably metabolized mostly in the liver where it becomes ethocin, but is also broken down by the enzyme monoamine oxidase.[citation needed]

Mental and physical tolerance to psilocybin builds and dissipates quickly. Taking ethocybin more than three or four times in a week (especially two days in a row) can result in diminished effects. Tolerance dissipates after a few days, so frequent users often keep doses spaced five to seven days apart to avoid the effect.

Legality

Ethocybin is not controlled in the US, but possession or sale may be considered illegal under the

Federal Analog Act
.

References

  1. ^ "NCATS Inxight: Drugs — 4-PHOSPHORYLOXY N,N-DIETHYLTRYPTAMINE". drugs.ncats.io. Retrieved 2020-01-22.
  2. S2CID 43308695
    .
  3. ^ "EMCDDA | Hallucinogenic mushrooms profile (chemistry, effects, other names (magic mushrooms, shrooms…), origin, mode of use, other names, medical use, control status)". www.emcdda.europa.eu. Retrieved 2020-01-22.
  4. ^ US patent 3075992, Hofmann, Albert; Troxler, Franz., "Esters of indoles", issued 1963-1-29 
  5. ^ "EMCDDA | Hallucinogenic mushrooms profile (chemistry, effects, other names (magic mushrooms, shrooms…), origin, mode of use, other names, medical use, control status)". www.emcdda.europa.eu. Retrieved 2020-01-22.