Ethyl loflazepate

Source: Wikipedia, the free encyclopedia.
Ethyl loflazepate
Clinical data
Trade namesVictan, Meilax, Ronlax
AHFS/Drugs.comInternational Drug Names
Pregnancy
category
  • ?
Routes of
administration		Oral
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability?
MetabolismHepatic
Elimination half-life51-103 h
ExcretionRenal
Identifiers
  • ethyl 7-chloro-5-(2-fluorophenyl)-2-oxo-1,3-dihydro-1,4-benzodiazepine-3-carboxylate
JSmol)
  • FC1=CC=CC=C1C2=NC(C(OCC)=O)C(NC3=C2C=C(C=C3)Cl)=O
  • InChI=1S/C18H14ClFN2O3/c1-2-25-18(24)16-17(23)21-14-8-7-10(19)9-12(14)15(22-16)11-5-3-4-6-13(11)20/h3-9,16H,2H2,1H3,(H,21,23) checkY
  • Key:CUCHJCMWNFEYOM-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Ethyl loflazepate

sleepiness, agitation and ataxia. Hypotonia may also occur in severe cases. These symptoms occur much more frequently and severely in children.[13] Death from therapeutic maintenance doses of ethyl loflazepate taken for 2 – 3 weeks has been reported in 3 elderly patients. The cause of death was asphyxia due to benzodiazepine toxicity.[14] High doses of the antidepressant fluvoxamine may potentiate the adverse effects of ethyl loflazepate.[15]

Ethyl loflazeplate is commercialized in Mexico, under the trade name Victan. It is officially approved for the following conditions:[16][17]

See also

References

  1. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  2. ^ DE 2012190 
  3. PMID 2904268
    .
  4. S2CID 31310535
    .
  5. ^ "Benzodiazepine Names". non-benzodiazepines.org.uk. Archived from the original on 2008-12-08. Retrieved 2009-04-05.
  6. PMID 6142848
    .
  7. PMID 6116677
    .
  8. PMID 6112027
    .
  9. PMID 2861304
    .
  10. PMID 2866771
    .
  11. PMID 2864933
    .
  12. S2CID 2850707
    .
  13. PMID 1354907
    .
  14. PMID 15902983
    .
  15. PMID 11778459
    .
  16. ^ "Victan". saludzac.gob.mx/. Archived from the original on 2009-05-26. Retrieved 2009-12-25.
  17. ^ "VICTAN". Farmacia Guerra. Retrieved 2009-12-25.

External links

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