Everhardus Jacobus Ariëns
Everhardus Jacobus Ariëns | |
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Born | University of Utrecht | 29 January 1918
Known for | receptor theory and drug stereochemistry |
Awards |
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Scientific career | |
Fields | Catholic University of Nijmegen |
Everhardus Jacobus Ariëns (29 January 1918 – 3 March 2002) was a Dutch
Early life
Everhardus Ariëns grew up as the sixth of ten children in
Scientific activity
After World War II he worked in the laboratory of Prof. UG Bijlsma in the area of adrenergic substances and in 1950 both in the field of chemistry and medical doctorate. In 1951, Everhardus Ariëns moved to Nijmegen after there at the Catholic University of the Faculty of Pharmacology was established. From 1954 until his retirement he was employed there as a professor.
Based on his dissertation, he developed together with Jacques van Rossum, a method for quantification of pharmacological effects as a result of ligand-receptor interactions. The thesis developed the concepts of receptor affinity and intrinsic activity.[3] With the help of these terms he could describe the behavior of agonists and antagonists as well as the dual agonist / antagonist behavior of partial agonists. An important accomplishment of Ariëns was the establishment of experiments on isolated organs instead of the living animal (ex vivo), which quickly and reproducibly delivered data on the affinity and intrinsic activity of test substances.
Everhardus Ariëns was also active in the field of
Honors and awards
Everhardus Ariëns 1963 was honored at the second International Congress of Pharmacology in Prague with the Purkinje Medal. In 1970 he became member of the Royal Netherlands Academy of Arts and Sciences.[5] He also received the Dr. Saal van Zwanenberg Award (1972), the Medal of the Norwegian Poulsson Pharmacological Society (1973), the Scheele Award (1974), the Schmiedeberg Medal (1980) and the Smissman Award of the American Chemical Society (1985). Everhardus Ariëns was awarded honorary doctorates from universities
References
- ^ a b Timmerman H, Breimer DD. "Everhardus Jacobus Ariëns" (PDF). Biography (in Dutch). The Royal Netherlands Academy of Arts and Sciences. Archived from the original (PDF) on 2011-05-12. Retrieved 2013-03-24.
- ^ .
- PMID 13465302.
- S2CID 30916093.
- ^ "Everhardus Jacobus Ariëns (1918 - 2002)". Royal Netherlands Academy of Arts and Sciences. Retrieved 18 July 2015.
Further reading
- Ariëns EJ, ed. (1964). Molecular Pharmacology: The Mode of Action of Biologically Active Compounds. Vol. 1. New York: Academic Press. pp. 503. ISBN 0120604019.
- Ariëns EJ, ed. (1971). Drug Design (Medicinal Chemical Monograph). Boston: Academic Press. ISBN 0-12-060301-2.
- Timmermans PBMWM; Ariëns EJ; Soudijn W (1983). Stereochemistry and biological activity of drugs. London: Blackwell Scientific Publications. p. 204. ISBN 0-632-01155-6.
External links
- "E. J. Ariens". ACSMEDI Hall of Fame. American Chemical Society.