FABP7
| FABP7 | |||
|---|---|---|---|
Gene ontology | |||
| Molecular function | |||
| Cellular component | |||
| Biological process | |||
| Sources:Amigo / QuickGO | |||
Ensembl | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 6: 122.78 – 122.78 Mb | Chr 10: 57.66 – 57.66 Mb | |||||||
| PubMed search | [3] | [4] | |||||||
| View/Edit Human | View/Edit Mouse |
Fatty acid binding protein 7, brain (FABP7; also brain lipid binding protein, BLBP), is a human gene.[5]
Function
The protein encoded by this gene is a brain fatty acid binding protein.
Fatty acid binding proteins (FABPs) are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. FABPs are thought to play roles in fatty acid uptake, transport, and metabolism.[5]
FABP7 is expressed, during development, in
Notch-1 activation.[7]
According to one study, FABP7 binds
affinity among all of the FABPs.[8]
radial glia, where neurogenesis
is prominent.Role in pathology
FABP7 maps onto human chromosome 6q22.31, a schizophrenia linkage region corroborated by a meta-analysis.[9]
As of 2008, two studies have been conducted into FABP7 as a possible risk gene for schizophrenia,[10] with one, that tested for only one SNP, showing negative[11] and another, with seven SNPs,[12] a positive result. The effect of the gene in the latter study was stronger in males. This study also linked FABP7 variation to weak prepulse inhibition in mice; deficit in PPI is an endophenotypic trait observed in schizophrenia patients and their relatives.
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000164434 – Ensembl, May 2017
- ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000019874 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "Entrez Gene: FABP7 fatty acid binding protein 7, brain".
- PMID 15879553.
- PMID 18593473.
- PMID 8798739.
- PMID 12802786.
- ^ Gene Overview of All Published Schizophrenia-Association Studies for FABP7 - SZGene database at Schizophrenia Research Forum website.
- PMID 17893707.
- PMID 18001149.
Further reading
- Börchers T, Hohoff C, Buhlmann C, Spener F (Jul 1997). "Heart-type fatty acid binding protein - involvement in growth inhibition and differentiation". Prostaglandins, Leukotrienes, and Essential Fatty Acids. 57 (1): 77–84. PMID 9250612.
- Xu LZ, Sánchez R, Sali A, Heintz N (Oct 1996). "Ligand specificity of brain lipid-binding protein". The Journal of Biological Chemistry. 271 (40): 24711–9. PMID 8798739.
- Young JK, Baker JH, Muller T (Mar 1996). "Immunoreactivity for brain-fatty acid binding protein in gomori-positive astrocytes". Glia. 16 (3): 218–26. S2CID 9757285.
- Shi YE, Ni J, Xiao G, Liu YE, Fuchs A, Yu G, Su J, Cosgrove JM, Xing L, Zhang M, Li J, Aggarwal BB, Meager A, Gentz R (Aug 1997). "Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG". Cancer Research. 57 (15): 3084–91. PMID 9242429.
- Shimizu F, Watanabe TK, Shinomiya H, Nakamura Y, Fujiwara T (Oct 1997). "Isolation and expression of a cDNA for human brain fatty acid-binding protein (B-FABP)". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1354 (1): 24–8. PMID 9375786.
- Godbout R, Bisgrove DA, Shkolny D, Day RS (Apr 1998). "Correlation of B-FABP and GFAP expression in malignant glioma". Oncogene. 16 (15): 1955–62. PMID 9591779.
- Pu L, Igbavboa U, Wood WG, Roths JB, Kier AB, Spener F, Schroeder F (Aug 1999). "Expression of fatty acid binding proteins is altered in aged mouse brain". Molecular and Cellular Biochemistry. 198 (1–2): 69–78. S2CID 6180992.
- Balendiran GK, Schnutgen F, Scapin G, Borchers T, Xhong N, Lim K, Godbout R, Spener F, Sacchettini JC (Sep 2000). "Crystal structure and thermodynamic analysis of human brain fatty acid-binding protein". The Journal of Biological Chemistry. 275 (35): 27045–54. PMID 10854433.
- Rademacher M, Zimmerman AW, Rüterjans H, Veerkamp JH, Lücke C (Oct 2002). "Solution structure of fatty acid-binding protein from human brain". Molecular and Cellular Biochemistry. 239 (1–2): 61–8. S2CID 24296178.
- Miller SJ, Li H, Rizvi TA, Huang Y, Johansson G, Bowersock J, Sidani A, Vitullo J, Vogel K, Parysek LM, DeClue JE, Ratner N (Mar 2003). "Brain lipid binding protein in axon-Schwann cell interactions and peripheral nerve tumorigenesis". Molecular and Cellular Biology. 23 (6): 2213–24. PMID 12612091.
- Sánchez-Font MF, Bosch-Comas A, Gonzàlez-Duarte R, Marfany G (Jun 2003). "Overexpression of FABP7 in Down syndrome fetal brains is associated with PKNOX1 gene-dosage imbalance". Nucleic Acids Research. 31 (11): 2769–77. PMID 12771203.
- Wang M, Liu YE, Goldberg ID, Shi YE (Nov 2003). "Induction of mammary gland differentiation in transgenic mice by the fatty acid-binding protein MRG". The Journal of Biological Chemistry. 278 (47): 47319–25. PMID 12975368.
- Liang Y, Diehn M, Watson N, Bollen AW, Aldape KD, Nicholas MK, PMID 15827123.
- Liang Y, Bollen AW, Aldape KD, Gupta N (2006). "Nuclear FABP7 immunoreactivity is preferentially expressed in infiltrative glioma and is associated with poor prognosis in EGFR-overexpressing glioblastoma". BMC Cancer. 6: 97. PMID 16623952.
- Kaloshi G, Mokhtari K, Carpentier C, Taillibert S, Lejeune J, Marie Y, Delattre JY, Godbout R, Sanson M (Sep 2007). "FABP7 expression in glioblastomas: relation to prognosis, invasion and EGFR status". Journal of Neuro-Oncology. 84 (3): 245–8. S2CID 23880935.
- Takaoka N, Takayama T, Teratani T, Sugiyama T, Mugiya S, Ozono S (2011). "Analysis of the regulation of fatty acid binding protein 7 expression in human renal carcinoma cell lines". BMC Molecular Biology. 12 (1): 31. PMID 21771320.
External links
- Schizophrenia, Startled Response & Fabp7: Future Dietary Changes for At-Risk Mothers? Schizophrenia Daily News Blog, 2007-11-07
- Gross L (2007). "A Candidate Gene for a Biological Marker of Schizophrenia in Mice". PLOS Biology. 5 (11): e320. PMID 20076655. - a synopsis for the general audience.
- Overview of all the structural information available in the PDB for UniProt: O15540 (Fatty acid-binding protein, brain) at the PDBe-KB.
PDB gallery | |
|---|---|
|
