Forkhead box d1
Ensembl |
| ||||||||
|---|---|---|---|---|---|---|---|---|---|
| UniProt | |||||||||
| RefSeq (mRNA) | |||||||||
| RefSeq (protein) | |||||||||
| Location (UCSC) | Chr 5: 73.44 – 73.45 Mb | n/a | |||||||
| PubMed search | [2] | [3] | |||||||
| View/Edit Human | View/Edit Mouse |
Forkhead box D1 is a protein that in humans is encoded by the FOXD1 gene.[4] Forkhead d1 is a kidney expressed transcription factor maps at the chromosome 5 at position 5q12—q13, identified in Drosophila forkhead protein and mammalian HNF3 transcription factor.[5] The name of was derived from two spiked head structures in the embryos of Drosophila forkhead mutant.[5] It belong to transcription factor family that displays remarkable functional diversity and involved in a wide variety of biological processes.[5] The most commonly used synonyms for Forkhead D1 are, FOX D1, FREAC-4 and BF2.[5]
Structure
The
Functions
Studies of the orthologous mouse protein indicate that it functions in kidney development by promoting nephron progenitor differentiation, and it also functions in the development of the retina and optic chiasm. It may also regulate inflammatory reactions and prevent autoimmunity.[4]
FOXD1 and
Foxd1 is also required for proper formation of
FOX D1 expressed and function in
Disease
The chromosomal duplication in the region 5q12-13 of chromosome 5 causes dysplastic kidneys and mental disorders which is relevant to tissue distribution o FREAC-4 mRNA.[5]
References
- ^ a b c GRCh38: Ensembl release 89: ENSG00000251493 – Ensembl, May 2017
- ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^ a b "FOX D1 Forkhead box D1".
- ^ PMID 12297093.
- ^ PMID 9403061.
- ^ PMID 8702877.
- ^ PMID 8666231.
- ^ PMID 15509772.
- ^ PMID 28075458.
- PMID 23284914.