Faldaprevir
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Other names | BI 201335 |
Routes of administration | By mouth |
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Faldaprevir was an experimental drug for the treatment of
Boehringer-Ingelheim and reached Phase III clinical trials in 2011.[1] Boehringer announced in 2014 that it would not pursue approval of the drug any more because of better HCV treatments having become available.[2]
Mechanism of action
Faldaprevir is a hepatitis C virus protease inhibitor.[citation needed]
Studies
Faldaprevir was tested in combination regimens with pegylated interferon and ribavirin, and in interferon-free regimens with other direct-acting antiviral agents including deleobuvir.[citation needed]
Data from the SOUND-C2 study, presented at the 2012
AASLD Liver Meeting, showed that a triple combination of faldaprevir, deleobuvir, and ribavirin performed well in HCV genotype 1b patients.[3]
References
- ^ Clinical trial number NCT01343888 for "Efficacy and Safety of BI 201335 (Faldaprevir) in Combination With Pegylated Interferon-alpha and Ribavirin in Treatment-naïve Genotype 1 Hepatitis C Infected Patients (STARTverso 1)" at ClinicalTrials.gov
- ^ "Hepatitis C: Aus für Boehringers Faldaprevir". www.pharmazeutische-zeitung.de.
- PMID 25749475.