CD64 (biology)
(Redirected from
FcγRI
)Chr. 1 q21.2-21.3 | |||||||
|---|---|---|---|---|---|---|---|
| |||||||
| Fc fragment of IgG, high affinity Ib, receptor (CD64) | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | FCGR1B | ||||||
Chr. 1 p11.2 | |||||||
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| Fc fragment of IgG, high affinity Ic, receptor (CD64) | |
|---|---|
| Identifiers | |
| Symbol | FCGR1C |
Chr. 1 q21.1 | |
CD64 (Cluster of Differentiation 64) is a type of
affinity.[1] It is more commonly known as Fc-gamma receptor 1 (FcγRI). After binding IgG, CD64 interacts with an accessory chain known as the common γ chain (γ chain), which possesses an ITAM motif that is necessary for triggering cellular activation.[2]
Structurally CD64 is composed of a
hydrophobic transmembrane domain, and a short cytoplasmic tail.[3]
CD64 is
There are three distinct (but highly similar)
mRNA transcripts; two from CD64A, three from CD64B, and one from CD64C; by alternate splicing.[3]
References
External links
- CD64+Antigens at the U.S. National Library of Medicine Medical Subject Headings (MeSH)