Fenproporex

Source: Wikipedia, the free encyclopedia.
Fenproporex
Clinical data
AHFS/Drugs.comInternational Drug Names
Routes of
administration		By mouth[1]
ATC code
  • none
Legal status
Legal status
Pharmacokinetic data
Metabolismpartly converted to amphetamine (30 to 60%)[1]
Excretionurine, mainly as amphetamine, about 5 to 9% unchanged[1]
Identifiers
  • 3-(1-phenylpropan-2-ylamino)propanenitrile
JSmol)
  • N#CCCNC(Cc1ccccc1)C
  • InChI=1S/C12H16N2/c1-11(14-9-5-8-13)10-12-6-3-2-4-7-12/h2-4,6-7,11,14H,5,9-10H2,1H3 checkY
  • Key:IQUFSXIQAFPIMR-UHFFFAOYSA-N checkY
 ☒NcheckY (what is this?)  (verify)

Fenproporex (Perphoxene) (N-2-Cyanoethylamphetamine) (3-(1-phenylpropan-2-ylamino)propanenitrile) (3-[(1-Methyl-2-Phenylethyl)amino]propiononitrile) is a

appetite suppressant for the treatment of obesity.[3]

Fenproporex produces

antidepressants, and other compounds to create a version of the "rainbow diet pill".[7][8][9]

Fenproporex has never been approved by the

US Food and Drug Administration (FDA) for sale in the US due to lack of efficacy and safety data. However, in March 2009, the FDA warned consumers that it has been detected as an unlabeled component of diet pills available over the Internet.[10] Fenproporex is designated a Schedule IV controlled substance in the US pursuant to the Controlled Substances Act.[11]

Fenproporex is on the list of

substances banned by the World Anti-Doping Agency, and any sportsperson testing positive for the substance faces a ban from competition.[12]

References

  1. ^
    ISBN 978-0-7923-0964-2
    .
  2. ^ Anvisa (2023-03-31). "RDC Nº 784 - Listas de Substâncias Entorpecentes, Psicotrópicas, Precursoras e Outras sob Controle Especial" [Collegiate Board Resolution No. 784 - Lists of Narcotic, Psychotropic, Precursor, and Other Substances under Special Control] (in Brazilian Portuguese). Diário Oficial da União (published 2023-04-04). Archived from the original on 2023-08-03. Retrieved 2023-08-16.
  3. ^ Warembourg H, Jaillard J. Clinical experimentation with fenproporex in the treatment of obesity. Apropos of 40 cases. (French). Journal de la Faculte de médecine et de pharmacie de l'Universite de Lille. 1968 Mar;13(3):Suppl:273-6.
  4. PMID 4637940
    .
  5. PMID 26270078
    .
  6. S2CID 39460850
    .
  7. PMID 19096898
    .
  8. S2CID 8730835
    .
  9. PMID 22813089
    .
  10. ^ "Consumer Directed Questions and Answers about FDA's Initiative Against Contaminated Weight Loss Products". FDA/Center for Drug Evaluation and Research. Archived from the original on 17 March 2009.
  11. ^ "21 CFR 1308.14(e)(4)". U.S. Government Printing Office. Archived from the original on 2011-10-16. Retrieved 2011-04-20.
  12. ^ The 2009 Prohibited List International Standard Archived February 3, 2009, at the Wayback Machine. World Anti-Doping Agency (2009). Retrieved on 2009-08-18.
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