Feodor Lynen
Feodor Felix Konrad Lynen | |
|---|---|
University of Munich Max Planck Society | |
| Doctoral advisor | Heinrich Otto Wieland |
| Doctoral students | Dieter Oesterhelt |
Feodor Felix Konrad Lynen
Biography
Feodor Lynen was born in
In 1964, he won the Nobel Prize in Physiology or Medicine together with Konrad Bloch for their discoveries concerning the mechanism and regulation of cholesterol and fatty acid metabolism. These discoveries took many years to work out.[4][5][6][7] The Nobel Committee felt that this was important because understanding the metabolism of sterols and fatty acids could reveal how cholesterol affects heart disease and stroke.[8] His Nobel Lecture on 11 December 1964 was 'The pathway from "activated acetic acid" to the terpenes and fatty acids'.[9]
Working mostly separately, Lynen and Bloch both discovered the steps that created squalene and turned the squalene into cholesterol. Initially, Lynen found that acetate activated by coenzyme A was needed to start the process. He discovered the chemical structure of acetyl-coenzyme A, which was needed for a detailed understanding of the biochemical pathways.[8] He also learned that biotin, or Vitamin B7, was needed for in the process.[9]
On 14 May 1937, Lynen married Eva Wieland (1915–2002), daughter of his academic teacher. They had five children between 1938 and 1946.[3] Feodor Lynen died in Munich, Germany, on 6 August 1979, six weeks after an operation for aneurism.[8]
Fellowship
The Alexander von Humboldt Foundation has a fellowship named in his honor.
Honours and awards
- 1962: elected to the American Academy of Arts and Sciences[10]
- 1962: elected to the United States National Academy of Sciences[11]
- 1963: Otto Warburg Medal from the German Society for Biochemistry and Molecular Biology [12]
- 1964: Konrad Bloch) "for their discoveries concerning the mechanism and regulation of the metabolism of cholesterol and fatty acids"
- 1965: Grand Cross of Merit with Star and Sash of the Federal Republic of Germany
- 1966: elected to the American Philosophical Society[13]
- 1967: Norman Medal of the German Society for Fat Research
- 1971: Pour le Mérite for Science and Art
- 1972: Austrian Decoration for Science and Art
References
- ^ JSTOR 769901.
- ISBN 9789810234126.
- ^ a b "Feodor Lynen — Biographical". Nobel Media AB. Retrieved 13 November 2013.
- PMID 13805544.
- PMID 4296920.
- PMID 5810824.
- PMID 5547468.
- ^ a b c "Feodor Lynen Biography (1911–1979)". Internet FAQ Archives. Retrieved 13 November 2013.
- ^ a b Lynen, Fyodor (11 December 1964). "The pathway from 'activated acetic acid' to the terpenes and fatty acids". Nobel Media AB.
- ^ "Feodor Felix Konrad Lynen". American Academy of Arts & Sciences. Retrieved 27 September 2022.
- ^ "Feodor Lynen". www.nasonline.org. Retrieved 27 September 2022.
- ^ "Otto-Warburg-Medal". GBM. Archived from the original on 4 November 2016. Retrieved 12 January 2014.
- ^ "APS Member History". search.amphilsoc.org. Retrieved 27 September 2022.
External links
- Feodor Lynen on Nobelprize.org
- Feodor Lynen's Nobel lecture, "The pathway from 'activated acetic acid' to the terpenes and fatty acids"
- Alexander von Humboldt Foundation, Feodor Lynen Research Fellowships
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