Fic/DOC protein family
| Fic/DOC family | |||||||||
|---|---|---|---|---|---|---|---|---|---|
 structure of cell filamentation protein (fic) from helicobacter pylori | |||||||||
| Identifiers | |||||||||
| Symbol | Fic | ||||||||
| Pfam | PF02661 | ||||||||
| InterPro | IPR003812 | ||||||||
| |||||||||
In molecular biology, the Fic/DOC protein family is a
motif HPFX[D/E]GNGR in most members and it carries the invariant catalytic histidine.[1] Fic domain was found in bacteria, eukaryotes and archaea and can be found organized in almost hundred different multi-domain assemblies.[1]
Functions
First fic gene was discovered in the late 1980s in
copy number plasmid. The frequency with which viable cells cured of prophage are produced is about 10(-5) per cell per generation.[8] A significant part of this remarkable stability can be attributed to a plasmid-encoded toxin-antitoxin module phd-doc causes death of cells that have lost P1.[9] Overall bacterial Fic proteins are members of toxin-antitoxin systems and other proteins involved in stress responses and infections.[1] The sole animal Fic-domain protein called HYPE or FICD is involved in proteostasis control by addition and removal of AMP from endoplasmic reticulum chaperone BIP.[10][1]