File:HIF Nobel Prize Physiology Medicine 2019 Hegasy ENG.png

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English: Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability. Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. The protein then associates with VHL and is subsequently tagged with ubiquitin. Tagged Hif-1 alpha is then translocated to the proteasome, where it is degraded. Under hypoxic conditions, no oxygen is available for proline hydroxylation. In this situation Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta, also termed ARNT. This complex then binds to a DNA region termed HRE (hypoxia responsive element). As a consequence target genes are transcribed. These genes are involved in the regulation of a multitude of processes, including erythropoesis, glycolysis and angiogenesis.
Date
Source Own work
Author Dr. Guido Hegasy

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Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability

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Date/TimeThumbnailDimensionsUserComment
current12:07, 9 October 2019Thumbnail for version as of 12:07, 9 October 20193,508 × 2,480 (1.26 MB)Guido4Typo corrected, changed some colors
16:06, 8 October 2019Thumbnail for version as of 16:06, 8 October 20193,508 × 2,480 (1.26 MB)Guido4User created page with UploadWizard
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