File:PBP catalysis.svg

Page contents not supported in other languages.
This is a file from the Wikimedia Commons
Source: Wikipedia, the free encyclopedia.

Original file(SVG file, nominally 1,142 × 1,567 pixels, file size: 1.44 MB)

Summary

Description
English: Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme).

1. The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-acetylmuramic acid (NAM) subunits. The NAM subunits have short peptide chains attached to them. (The exact composition of these can vary. The proximal alanine is usually L-ala and the distal two are usually D-ala.) These chains, in turn, are bound to chains of 5 glycine residues that will be used in cross-linking.

2. The PBP forms a bond with the peptide side chain at the second most distal alanine residue. This displaces the most distal alanine residue.

3. Another strand of bacterial cell wall arrives. The free end of one of the pentaglycine chains displaces the PBP and forms a bond with the terminal alanine on the other strand.

4. After being displaced, the PBP diffuses away.

5. The formation of one cross-link is complete.
Date
Source Own work
Author Mcstrother
Other versions

[edit]

  • Cross-linking of bacteria cell wall with no antibiotics.
    Cross-linking of bacteria cell wall with no antibiotics.
  • Action of penicillin
    Action of penicillin
  • Resistance to penicillin via modified cross-linking enzyme.
    Resistance to penicillin via modified cross-linking enzyme.
  • Action of vancomycin and resistance via alteration of peptide side-chains.
    Action of vancomycin and resistance via alteration of peptide side-chains.
  • Spanish version.
    Spanish version.

Licensing

I, the copyright holder of this work, hereby publish it under the following license:
w:en:Creative Commons
attribution
This file is licensed under the Creative Commons Attribution 3.0 Unported license.
You are free:
  • to share – to copy, distribute and transmit the work
  • to remix – to adapt the work
Under the following conditions:
  • attribution – You must give appropriate credit, provide a link to the license, and indicate if changes were made. You may do so in any reasonable manner, but not in any way that suggests the licensor endorses you or your use.

Captions

Add a one-line explanation of what this file represents

Items portrayed in this file

depicts

6 March 2011

File history

Click on a date/time to view the file as it appeared at that time.

Date/TimeThumbnailDimensionsUserComment
current19:26, 9 September 2011Thumbnail for version as of 19:26, 9 September 20111,142 × 1,567 (1.44 MB)McstrotherMajor revision. Corrected inaccuracies in previous image.
04:15, 3 May 2011Thumbnail for version as of 04:15, 3 May 20111,139 × 1,062 (850 KB)McstrotherChanged all fonts to Liberation Sans
03:46, 10 April 2011Thumbnail for version as of 03:46, 10 April 20111,139 × 1,062 (850 KB)McstrotherChanged color of carbohydrate chain.
03:30, 7 March 2011Thumbnail for version as of 03:30, 7 March 20111,139 × 1,062 (835 KB)Mcstrother{{Information |Description ={{en|1=Diagram depicting formation of cross-links in the bacterial cell wall by a penicillin binding protein (PBP, an enzyme). 1. The bacterial cell wall consists of strands of repeating N-acetylglucosamine (NAG) and N-ace
The following pages on the English Wikipedia use this file (pages on other projects are not listed):

Global file usage

The following other wikis use this file:

Metadata