Filociclovir

Filociclovir
Legal status
Legal status	US: Investigational New Drug;
Identifiers
	IUPAC name 2-amino-9-[(Z)-[2,2-bis(hydroxymethyl)cyclopropylidene]methyl]-1H-purin-6-one;
JSmol)	Interactive image;
	SMILES C1/C(=C/N2C=NC3=C2N=C(NC3=O)N)/C1(CO)CO;
	InChI InChI=1S/C11H13N5O3/c12-10-14-8-7(9(19)15-10)13-5-16(8)2-6-1-11(6,3-17)4-18/h2,5,17-18H,1,3-4H2,(H3,12,14,15,19)/b6-2-; Key:KMUNHOKTIVSFRA-KXFIGUGUSA-N;

Filociclovir (cyclopropavir, MBX-400) is an

antiviral drug which was developed for the treatment of cytomegalovirus infection and also shows some activity against other double-stranded DNA viruses. It has reached Phase II human clinical trials.^[1]^[2]^[3]

References

PMID 30677427
.

PMID 31285228
.

S2CID 210333445
.

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DNA virus antivirals (primarily J05, also S01AD and D06BB)
Baltimore I
Herpesvirus
DNA-synthesis
inhibitor
TK activated
Purine analogue

guanine (Aciclovir^#/Valaciclovir

Ganciclovir/Valganciclovir^#

Penciclovir/Famciclovir)

adenine (Vidarabine)

Pyrimidine analogue

uridine (Idoxuridine

Trifluridine (+tipiracil)

Edoxudine)

thymine
Brivudine

FV-100^†

Sorivudine^‡

cytosine (Cytarabine)

Not TK activated

Foscarnet

Other

Amenamevir

Docosanol

Letermovir

Maribavir

early protein (Fomivirsen^‡)

Tromantadine

HPV/MC

Imiquimod/Resiquimod

Podophyllotoxin

Vaccinia

assembly: Rifampicin

Poxviridae

Methisazone

Tecovirimat

Hepatitis B (VII)

Nucleoside analogues/NARTIs: Entecavir^#

Lamivudine

Lobucavir^†

Telbivudine

Clevudine

Nucleotide analogues/NtRTIs: Adefovir

Tenofovir disoproxil

Tenofovir alafenamide

Multiple/general
Nucleic acid inhibitors

Cidofovir

Brincidofovir

Interferon

Interferon alfa 2b

Peginterferon alfa-2a

Multiple/unknown

Filociclovir^†

Ribavirin^#/Taribavirin^†

Moroxydine

^#WHO-EM

^‡Withdrawn from market

Clinical trials:
^†Phase III

^§Never to phase III

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v
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[1] PMID 30677427
.

[2] PMID 31285228
.

[3] S2CID 210333445
.

[1]

[2]

[3]