Floctafenine

Source: Wikipedia, the free encyclopedia.
Floctafenine
Clinical data
AHFS/Drugs.comInternational Drug Names
ATC code
Identifiers
  • 2,3-Dihydroxypropyl 2-{[8-(trifluoromethyl)-4-quinolinyl]amino}benzoate
JSmol)
  • FC(F)(F)c1cccc2c(ccnc12)Nc3ccccc3C(=O)OCC(O)CO
  • InChI=1S/C20H17F3N2O4/c21-20(22,23)15-6-3-5-13-17(8-9-24-18(13)15)25-16-7-2-1-4-14(16)19(28)29-11-12(27)10-26/h1-9,12,26-27H,10-11H2,(H,24,25)
  • Key:APQPGQGAWABJLN-UHFFFAOYSA-N

Floctafenine is a nonsteroidal anti-inflammatory drug (NSAID).

Synthesis

Floctafenine can be synthesized beginning with the conversion of ortho-trifluoromethyl aniline (1) to a

phosphorus oxychloride. The displacement of chlorine with methyl anthranilate (4) then affords the coupled intermediate (5). An ester interchange of that product with glycerol
leads to the glyceryl ester, floctafenine (6).

Flocatfenine synthesis

See also

References

  1. Roussel-Uclaf
     
  2. ^ U.S. patent 3,644,368 Roussel Uclaf
  3. S2CID 97164628
    .
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