Fluminorex

Source: Wikipedia, the free encyclopedia.
Fluminorex
Clinical data
ATC code
  • none
Identifiers
  • (RS)-5-[4-(trifluoromethyl)phenyl]-4,5-dihydro-1,3-oxazol-2-amine
JSmol)
ChiralityRacemic mixture
  • FC(F)(F)c1ccc(cc1)C2O\C(=N/C2)N
  • InChI=1S/C10H9F3N2O/c11-10(12,13)7-3-1-6(2-4-7)8-5-15-9(14)16-8/h1-4,8H,5H2,(H2,14,15) checkY
  • Key:NMGYDYBWRZHLHR-UHFFFAOYSA-N checkY
  (verify)

Fluminorex is a centrally acting

appetite suppressant by McNeil Laboratories in the 1950s.[1][2]

Synthesis

Synthesis:[3] Patent (Ex XV):[4]

2-amino-1-[4-(trifluoromethyl)phenyl]ethanol [776-02-3] (1) cyanogen bromide [506-68-3] (2)

See also

References

  1. ^ US Patent 3278382 - 2-amino-5-aryloxazoline compositions and methods of using same
  2. PMID 30269490
    .
  3. PMID 14185981
    .
  4. ^ Poos George Ireland, U.S. patent 3,278,382 (1966 to Janssen Pharmaceuticals Inc).


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