Fluocinonide

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Fluocinonide
Topical
ATC code
Legal status
Legal status
  • AU: S4 (Prescription only)
  • UK: POM (Prescription only)
  • US: WARNING[2]Rx-only
Pharmacokinetic data
MetabolismLiver
Identifiers
  • 6α,9-difluoro-11β,16α,17,21-tetrahydroxypregna-1,4-diene-3,20-dione, cyclic 16,17-acetal with acetone,21-acetate
JSmol)
  • O=C(OCC(=O)[C@]45OC(O[C@@H]5C[C@@H]2[C@@]4(C[C@H](O)[C@]3(F)[C@]/1(/C=C\C(=O)\C=C\1[C@@H](F)C[C@@H]23)C)C)(C)C)C
  • InChI=1S/C26H32F2O7/c1-13(29)33-12-20(32)26-21(34-22(2,3)35-26)10-15-16-9-18(27)17-8-14(30)6-7-23(17,4)25(16,28)19(31)11-24(15,26)5/h6-8,15-16,18-19,21,31H,9-12H2,1-5H3/t15-,16-,18-,19-,21+,23-,24-,25-,26+/m0/s1 checkY
  • Key:WJOHZNCJWYWUJD-IUGZLZTKSA-N checkY
  (verify)

Fluocinonide is a potent

eczema and seborrhoeic dermatitis.[3] It relieves itching, redness, dryness, crusting, scaling, inflammation, and discomfort.[3]

A common potential adverse effect is skin atrophy (thinning of the skin).[4]

In 2021, it was the 249th most commonly prescribed medication in the United States, with more than 1 million prescriptions.[5][6]

Veterinary uses

Fluocinonide is used in veterinary medicine. It is a treatment for allergies in dogs.[7] Natural systemic cortisol concentrations can be suppressed for weeks after one week of topical exposure.[8]

References

  1. ^ "Fluocinonide Topical". MedlinePlus Drug Information. U.S. National Library of Medicine.
  2. FDA
    . Retrieved 22 October 2023.
  3. ^ a b "Fluocinonide Topical: MedlinePlus Drug Information". medlineplus.gov. Retrieved 16 November 2022.
  4. S2CID 30656827
    .
  5. ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
  6. ^ "Fluocinonide - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
  7. ^ Dog Allergies. Squidoo (Report).
  8. PMID 2824410
    .
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