Fluticasone furoate
Clinical data | |
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Trade names | Flonase Sensimist, Veramyst, Arnuity Ellipta, others |
AHFS/Drugs.com | Monograph |
License data | |
Pregnancy category |
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Routes of administration | Intranasal, by mouth |
ATC code | |
Legal status | |
Legal status | |
Pharmacokinetic data | |
Bioavailability | 0.51% (Intranasal) |
Protein binding | 91% |
Metabolism | Intranasal Liver (CYP3A4-mediated) |
Elimination half-life | 15 hours |
Excretion | Kidney |
Identifiers | |
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JSmol) | |
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Fluticasone furoate, sold under the brand name Flonase Sensimist among others, is a corticosteroid for the treatment of non-allergic and allergic rhinitis administered by a nasal spray.[9] It is also available as an inhaled corticosteroid to help prevent and control symptoms of asthma. It is derived from cortisol.[10] Unlike fluticasone propionate, which is only approved for children four years and older, fluticasone furoate is approved in children as young as two years of age when used for allergies.[6][11]
It was approved for medical use in the United States in April 2007, and in the European Union in November 2008.[12][8] In 2021, fluticasone was the 23rd most commonly prescribed medication in the United States, with more than 25 million prescriptions.[13][14]
Medical uses
Fluticasone furoate is
Society and culture
Brand names
In the US it is marketed by
The combination drugs fluticasone furoate/umeclidinium bromide/vilanterol, marketed as Trelegy Ellipta, and fluticasone furoate/vilanterol, marketed as Breo Ellipta (US, Canada, New Zealand) and Relvar Ellipta (EU, UK),[15][16][17] are approved for use in the United States for long-term maintenance treatment of airflow obstruction in people with chronic obstructive pulmonary disease (COPD).[15] They are also approved for the treatment of asthma.[15][18]
The combination
References
- ^ "Fluticasone Use During Pregnancy". Drugs.com. 9 January 2019. Archived from the original on 26 March 2019. Retrieved 4 February 2020.
- ^ "AVAMYS fluticasone furoate nasal spray bottle (131443)". Department of Health and Ages Care. Archived from the original on 2 March 2023. Retrieved 1 April 2023.
- ^ "Arnuity Elliptafluticasone furoate 50 microgram powder for inhalation dry powder inhaler (300141)". Department of Health and Ages Care. Archived from the original on 2 March 2023. Retrieved 1 April 2023.
- ^ "Product monograph brand safety updates". Health Canada. 7 July 2016. Retrieved 3 April 2024.
- ^ "Avamys 27.5 micrograms/spray, nasal spray suspension - Summary of Product Characteristics (SmPC)". (emc). 4 June 2021. Archived from the original on 8 June 2023. Retrieved 18 June 2023.
- ^ a b c d e "Flonase Sensimist Allergy Relief- fluticasone furoate spray, metered". DailyMed. 30 May 2019. Archived from the original on 2 December 2020. Retrieved 4 February 2020.
- ^ a b c "Arnuity Ellipta- fluticasone furoate powder". DailyMed. 26 June 2019. Archived from the original on 7 December 2019. Retrieved 4 February 2020.
- ^ a b c "Avamys EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 5 June 2020. Retrieved 5 June 2020.
- from the original on 18 May 2019. Retrieved 18 May 2019.
- ISBN 9781455709328.
- ^ a b "Veramyst- fluticasone furoate spray, metered". DailyMed. 1 March 2010. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
- ^ "Drug Approval Package: Veramyst (fluticasone furoate) NDA #022051". U.S. Food and Drug Administration (FDA). 30 August 2010. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
- ^ "The Top 300 of 2021". ClinCalc. Archived from the original on 15 January 2024. Retrieved 14 January 2024.
- ^ "Fluticasone - Drug Usage Statistics". ClinCalc. Retrieved 14 January 2024.
- ^ a b c "Breo Ellipta- fluticasone furoate and vilanterol trifenatate powder". DailyMed. 7 January 2019. Archived from the original on 26 May 2020. Retrieved 4 February 2020.
- ^ "Relvar Ellipta 92 micrograms/22 micrograms inhalation powder, pre-dispensed - Summary of Product Characteristics (SmPC)". (emc). 3 January 2019. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
- ^ "Relvar Ellipta EPAR". European Medicines Agency (EMA). 17 September 2018. Archived from the original on 5 February 2020. Retrieved 4 February 2020.
- ^ "Is Trelegy used for asthma?". Drugs.com. Archived from the original on 18 April 2023. Retrieved 18 April 2023.
- ^ "Advair Diskus- fluticasone propionate and salmeterol powder". DailyMed. 20 October 2020. Archived from the original on 31 May 2023. Retrieved 18 June 2023.