Follicular B cell

Source: Wikipedia, the free encyclopedia.

Within the immune system, Follicular B cells (FO B cells) are a type of B cell that reside in primary and secondary lymphoid follicles (containing germinal centers) of secondary and tertiary lymphoid organs, including spleen and lymph nodes. Antibody responses against proteins are believed to involve follicular B cell pathways in secondary lymphoid organs.[1]

Mature B cells from the spleen can be divided into two main populations: FO B cells, which constitute the majority, and

marginal zone B-cells, lining outside the marginal sinus and bordering the red pulp
. FO B cells express high levels of
FDC as a guidance system for mature resting B cells in peripheral lymph nodes.[3] Unlike their MZ
counterpart, FO B cells freely recirculate, comprising >95% of the B cells in peripheral lymph nodes.

The BCR repertoire of the follicular B cell compartment also appears under positive selection pressures during final maturation in the spleen. However, diversity is substantially broader than B1 B and MZ B cell compartments. More importantly, FO B cells require CD40-CD40L dependent TFH cell help to promote effective primary immune responses and antibody isotype switching and to establish high-affinity B cell memory.[4]

References

  1. S2CID 9769697
    .
  2. ^ Miller MJ, Wei SH, Parker I, et al. Two-photon imaging of lymphocyte motility and antigen response in intact lymph node. Science. 2002;296(5574):1869–1873.
  3. ^ Bajenoff M, Egen JG, Koo LY, et al. Stromal cell networks regulate lymphocyte entry, migration, and territoriality in lymph nodes. Immunity. 2006;25(6):989–1001.
  4. ^ McHeyzer-Williams LJ, McHeyzer-Williams MG. Antigen-specific memory B cell development. Annu Rev Immunol. 2005;23:487–513.
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