Formetorex
Source: Wikipedia, the free encyclopedia.
Substituted amphetamine appetite suppressant drug
Names | |
---|---|
Preferred IUPAC name
N-(1-Phenylpropan-2-yl)formamide | |
Other names
Formetorex
N-Formylamphetamine N-(alpha-Methylphenethyl)formamide | |
Identifiers | |
3D model (
JSmol ) |
|
1563 | |
ChEMBL | |
ChemSpider | |
PubChem CID
|
|
UNII | |
CompTox Dashboard (EPA)
|
|
| |
| |
Properties | |
C10H13NO | |
Molar mass | 163.220 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Chemical compound
Formetorex (
INN), also known as formetamide or N-formylamphetamine, is a substituted amphetamine described as an anorectic which does not appear to have ever been marketed.[1]
Formetorex is also an
intermediate in the production of amphetamine by the "Leuckart reaction."[2] It is also commonly found as an impurity in clandestine labs where this synthesis method is used.[2][3] Due to the simplicity of the Leuckart reaction, it is the most popular synthetic route employed for the illicit manufacture of amphetamines.[2] The synthesis involves a non-metal reduction that is typically carried out in three steps.[2] For amphetamine synthesis, a mixture of phenylacetone and formamide (sometimes in the presence of formic acid) or ammonium formate, is heated until a condensation reaction results in the intermediate product, formetamide.[2] In the second step, formetamide is hydrolysed using hydrochloric acid, and the reaction mixture is then basified, isolated, and steam distilled to produce the free base.[2] The final step, the product is dissolved in an organic solvent and precipitated as the sulphate salt of amphetamine by adding sulfuric acid.[2]
References
- ISBN 978-0-412-46630-4.
- ^ ISBN 92-1-148208-9. Retrieved 14 October 2013.
- PMID 541629.
External links
- formetamide at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
|
| |
---|---|---|
Adrenergic agonists |
| |
Other |
|
antagonists
receptor agonists
- Beloranib§
- Bimagrumab§
- Desiccated thyroid‡
- Metformin
- Metreleptin
- Naltrexone
- Setmelanotide
- Topiramate
- ZGN-1061
- Zonisamide
- Water
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
Adamantanes | |
---|---|
Adenosine antagonists | |
Alkylamines | |
Ampakines | |
Arylcyclohexylamines | |
Benzazepines |
|
Cathinones |
|
Cholinergics |
|
Convulsants | |
Eugeroics | |
Oxazolines | |
Phenethylamines |
|
Phenylmorpholines | |
Piperazines | |
Piperidines |
|
Pyrrolidines |
|
Racetams | |
Tropanes |
|
Tryptamines |
|
Others |
|
ATC code: N06B |
Phenethylamines |
|
---|---|
Amphetamines |
|
Phentermines |
|
Cathinones |
|
Phenylisobutylamines | |
Phenylalkylpyrrolidines | |
Catecholamines (and close relatives) |
|
Miscellaneous |
|