Fospropofol

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Fospropofol
Clinical data
AHFS/Drugs.comMonograph
License data
Pregnancy
category
  • B
Dependence
liability		unknown
Routes of
administration		Intravenous
ATC code
Legal status
Legal status
Pharmacokinetic data
Protein binding98%[1]
MetabolismHepatic glucuronidation
Elimination half-life0.81 hours[1]
ExcretionRenal
Identifiers
  • disodium [2,6-di(propan-2-yl)phenoxy]methyl phosphate[2]
JSmol)
  • CC(C)c1cccc(c1OCOP(=O)(O)O)C(C)C
  • InChI=1S/C13H21O5P/c1-9(2)11-6-5-7-12(10(3)4)13(11)17-8-18-19(14,15)16/h5-7,9-10H,8H2,1-4H3,(H2,14,15,16) ☒N
  • Key:QVNNONOFASOXQV-UHFFFAOYSA-N ☒N
 ☒NcheckY (what is this?)  (verify)

Fospropofol (

diagnostic or therapeutic procedures such as endoscopy
.

Clinical applications

Several

bacteremia.[citation needed] Often, fospropofol is administered in conjunction with an opioid such as fentanyl.[citation needed
]

Clinical pharmacology

Mechanism of action

Fospropofol is a prodrug of propofol; as an organophosphate it is metabolized by alkaline phosphatases to phosphate and formaldehyde and the active metabolite, propofol.

Pharmacodynamics

Pharmacokinetics

Initial trial results on fospropofol pharmacokinetics were retracted by the investigators. As of 2011, new results were not available.[7]


Controlled substance

Fospropofol is classified as a Schedule IV controlled substance in the United States' Controlled Substances Act.[8]

See also

References

  1. ^ a b "LUSEDRA (fospropofol disodium) Injection" (PDF). Woodcliff Lake, New Jersey: Eisai Inc. October 2009. Archived from the original (PDF) on 22 November 2010. Retrieved 2 August 2010.
  2. ^ "Fospropofol disodium". PubChem Compound. Bethesda, Maryland: U.S. National Library of Medicine. Retrieved 9 February 2017.
  3. ^ "Recommended INNs 2006, pt 56" (PDF). World Health Organization. Retrieved 20 April 2016.
  4. ^ "FDA Approves Fospropofol and Follows ASAs Labeling Recommendation". American Society of Anesthesiologists. 2008-12-15. Archived from the original on 2011-05-26. Retrieved 2011-03-30.
  5. PMID 11294393
    .
  6. PMID 12781176
    .
  7. PMID 22345970
    .
  8. ^ "Schedule of Controlled Substances; Placement of Fospropofol into Schedule IV[permanent dead link]," 74 Federal Register 192 (October 6, 2009), pp. 51234–51236.
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