Frank Ruddle

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Frank Ruddle
Dickson Prize in Medicine (1982)
William Allan Award (1984)[1]
Scientific career
InstitutionsYale University
ThesisChromosome variation in cell populations (1960)
Doctoral studentsAnne Ferguson-Smith[2]

Francis Hugh Ruddle (1929–2013) was an American cell and developmental biologist who was the Sterling Professor at Yale University.[4] Ruddle was an early visionary of the Human Genome Project and created the first genetically modified mouse.[4] He was a pioneer in both human and mouse genetics.

Early life and education

Ruddle's parents, Thomas H. Ruddle and Mary Henley Rhodda Ruddle, immigrated from the United Kingdom to West New York, New Jersey, where Frank was born on August 19, 1929.[5][6] He grew up in Mariemont, Ohio, where Ruddle spent a lot of his childhood near the Ohio River.[6] Leaving high school early, Frank became a member of the United States Air Force in 1946 and fought for the country up until the year 1949.[5][7] With the help of the GI Bill, Frank was able to continue his education at Wayne State University, where he earned both his bachelor's degree and master's degree just two years apart.[5][7] During the year of 1960, he received his Ph.D. in zoology at the University of California at Berkeley.[5][7]

Career and projects

In 1961, the

Herpes simplex and SV-40, into new fertilized mouse eggs, which were then inserted into female mice.[10] The outcome consisted of animals that were partially mouse and partially non-mouse.[10] In 1974, Ruddle created the first ever Human Gene Mapping Workshop, and twelve years later, with Victor McKusick, began creating a new journal named Genomics, which the name now represents a whole branch of study.[11] The journal documented the development of many different fields connected to gene mapping.[11]

Awards and acknowledgements

In 1971, Ruddle became the president of the

Institute of Medicine in 1985, and the American Academy of Arts and Sciences in 1977.[12] In 1983, Ruddle received the William Alan Memorial Award by the American Society of Human Genetics.[12] Ruddle also received the Dickson Prize in Medicine.[8] Throughout his entire career, he contributed more than 900 publications to the field.[9]

References

  1. PMID 6594045
    .
  2. ProQuest 303744258
    .
  3. ^ In memoriam: Francis (Frank) Ruddle
  4. ^
    PMID 24242788
    .
  5. ^
    PMID 24242788
    .
  6. ^ a b "Professor Frank Ruddle | Biographical summary". WhatisBiotechnology.org. Retrieved 2021-10-16.
  7. ^
    PMID 23716665
    .
  8. ^ a b c d e f g "In memoriam: Francis (Frank) Ruddle". YaleNews. 2013-03-13. Retrieved 2021-11-04.
  9. ^ a b c "University of Glasgow :: Story :: Biography of Frank Ruddle". www.universitystory.gla.ac.uk. Retrieved 2021-11-04.
  10. ^
    ISSN 0362-4331
    . Retrieved 2021-11-04.
  11. ^
    PMID 23716665
    .
  12. ^
    PMID 23716665
    .
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