Franz Hillenkamp

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Franz Hillenkamp
Laser microprobe mass analyzer
Matrix-assisted laser desorption/ionization
AwardsDistinguished Contribution in Mass Spectrometry (1997)
Thomson Medal (2003)
Karl Heinz Beckurts Award (2003)
Scientific career
FieldsChemistry
InstitutionsUniversity of Münster

Franz Hillenkamp (March 18, 1936 – August 22, 2014) was a German scientist known for his development of the

laser microprobe mass analyzer[1][2] and, with Michael Karas, matrix-assisted laser desorption/ionization (MALDI).[3][4][5]

Early life and education

Franz Hillenkamp was born in 1936 in

Technische Universität München
in 1966 with a thesis entitled “An Absolutely Calibrated Calorimeter for the Measurement of Pulsed Laser Radiation.”

Academic career

Hillenkamp was a professor at Goethe University Frankfurt in Frankfurt from 1982 to 1986. In 1986, he became a professor on the Medical Faculty of the University of Münster where he remained until his retirement in 2001.

Laser microprobe

In 1973, Hillenkamp developed a high performance

attogram limit of detection for lithium atoms.[6] This instrument was commercialized as the LAMMA 500[7] and was one of the first laser desorption mass spectrometers to be used for mass spectrometry imaging of tissue.[5] The later LAMMA 1000 was also based on a Hillenkamp design.[8]

MALDI

In 1985, Hillenkamp and his colleague Michael Karas used a LAMMA 1000 mass spectrometer to demonstrate the technique of matrix-assisted laser desorption/ionization (MALDI).[9] MALDI is an ionization method used in mass spectrometry, allowing the analysis of large biopolymers. Although Karas and Hillenkamp were the first to discover MALDI, Japanese engineer Koichi Tanaka was the first to use a similar method in 1988 to ionize proteins[10] and shared the Nobel Prize in Chemistry in 2002 for that work.[11] Karas and Hillenkamp reported MALDI of proteins a few months later.[12] The MALDI method of Karas and Hillenkamp subsequently became the much more widely used method.[13]

Awards

In 1997, Hillenkamp and Karas were awarded the American Society for Mass Spectrometry Distinguished Contribution in Mass Spectrometry award for their discovery of MALDI.[14] Hillenkamp and Karas received the Karl Heinz Beckurts Award, Germany's most important award for outstanding promotion of the partnership between science and industry, in 2003.[15][16] Hillenkamp received the Thomson Medal from the International Mass Spectrometry Foundation in 2003.[17]


SPIE, the international society for optics and photonics created a postdoctoral fellowship in honor of Franz Hillenkamp. The SPIE-Franz Hillenkamp Postdoctoral Fellowship in Problem-Driven Biomedical Optics and Analytics offers an annual grant of US $75,000. This fellowship aims to facilitate the translation of cutting-edge biomedical optics and biophotonics technologies into practical applications within clinical settings, ultimately contributing to advancements in human healthcare.

See also

References

  1. S2CID 135753888
    .
  2. ISSN 0003-2700
    .
  3. ISBN 978-3-527-61047-1
    .
  4. ^ Völker, Karin (2014-08-26). "Trauer um Biophysiker Franz Hillenkamp - Er verpasste den Nobelpreis" [Mourning biophysicist Franz Hillenkamp - He missed the Nobel Prize]. Westfälische Nachrichten (in German). Retrieved 2014-08-27.
  5. ^
    PMID 25331412
    .
  6. S2CID 4163087
    .
  7. S2CID 92151249
    .
  8. ISSN 0020-7381
    .
  9. doi:10.1021/ac00291a042
    .
  10. doi:10.1002/rcm.1290020802
    .
  11. ^ "The Nobel Prize in Chemistry 2002". The Nobel Foundation. 9 October 2002. Retrieved 2013-01-31.
  12. PMID 3239801. Archived from the original
    (PDF) on 2006-06-23.
  13. ^ Spinney, Laura (December 11, 2002). "Nobel Prize controversy". The Scientist. Archived from the original on May 17, 2007. Retrieved 2007-08-29.
  14. ISBN 978-0-941901-31-4
    .
  15. ^ "Preisträger - Karl Heinz Beckurts-Stiftung Preisträger" [Karl Heinz Beckurts Foundation Award Winners] (in German). Retrieved 2014-08-31.
  16. ^ "Professoren Hillenkamp (Münster) und Karas (Frankfurt) erhalten Karl Heinz-Beckurts-Preis 2003" [Professors Hillenkamp (Münster) and Karas (Frankfurt) Receive Karl Heinz Beckurts Award 2003] (in German). Universität Münster. 2003-12-05. Archived from the original on 2012-03-04. Retrieved 2014-08-31.
  17. S2CID 192590730
    .

External links
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