Frontal fibrosing alopecia

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Frontal fibrosing alopecia
Other namesFFA[1]
SpecialtyDermatology

Frontal fibrosing alopecia is the frontotemporal

lichen planopilaris.[4]

Presentation

There is loss of both

lichen planus pigmentosus is present.[10]

Associations

Frontal fibrosing alopecia has been most often reported in post-menopausal women with higher levels of affluence and a negative smoking history. Autoimmune disease is found in 30% of patients.[6][11]

Pathogenesis

Although the pathogenesis of frontal fibrosing alopecia is poorly understood, autoimmune reaction and hormonal factors may play a role.[6]

Diagnostic

Perifollicular erythema and scarring white patches are seen on dermoscopy. On scalp biopsy, lymphocytic and granulomatous perifolliculitis with eccentric atrophy of follicular epithelia and perifollicular fibrosis are visualized.[12]

Differential diagnosis

Important diagnoses to consider include

female pattern hair loss (FPHL), chronic telogen effluvium (CTE), and alopecia areata (AA). FPHL is a non-scarring progressive miniaturization of the hair follicle with one of three different characteristic patterns. CTE is an idiopathic disease causing increased hair shedding and bi-temporal recession, usually in middle aged women. AA is an autoimmune attack of hair follicles that usually causes hair to fall out in small round patches.[13]

Treatment

Improvement or stabilization of the condition has been reported with topical and intralesional

5α-reductase inhibitors. In one study, the use of antiandrogens
(finasteride or dutasteride) was associated with improvement in 47% and stabilization in 53% of patients [14] Recently, successful treatment of facial papules in patients with frontal fibrosing alopecia was described with oral isotretinoin.[15]

See also

  • Skin lesion

References

  1. ^ RESERVED, INSERM US14-- ALL RIGHTS. "Orphanet: Frontal fibrosing alopecia". www.orpha.net. Retrieved 26 April 2019.{{cite web}}: CS1 maint: numeric names: authors list (link)
  2. PMID 35899069
    .
  3. ISBN 0-07-138076-0
    .
  4. S2CID 9044042
    .
  5. ^ Kossard S, Lee MS, Wilkinson B. Postmenopausal alopecia: a frontal variant of lichen planopilaris. J Am Acad Dermatol. 1997;36(1):59.
  6. ^ a b c Macdonald A, Clark C, Holmes S. Frontal fibrosing alopecia: a review of 60 cases. J Am Acad Dermatol. 2012;67(5):955-61.
  7. ^ Banka N, Mubki T, Bunagan MJ, Mcelwee K, Shapiro J. Frontal fibrosing alopecia: a retrospective clinical review of 62 patients with treatment outcome and long-term follow-up. Int J Dermatol. 2014;53(11):1324-30.
  8. ^ Pirmez R, Donati A, Valente NS, Sodré CT, Tosti A. Glabellar red dots in frontal fibrosing alopecia: a further clinical sign of vellus follicle involvement. Br J Dermatol. 2014;170(3):745-6.
  9. ^ Vañó-galván S, Rodrigues-barata AR, Urech M, et al. Depression of the frontal veins: A new clinical sign of frontal fibrosing alopecia. J Am Acad Dermatol. 2015;72(6):1087-8.
  10. ^ Pirmez R, Duque-Estrada B, Donati A, Campos-do-Carmo G, Valente NS, Romiti R, Sodré CT, Tosti A. Clinical and dermoscopic features of lichen planus pigmentosus in 37 patients with frontal fibrosing alopecia. Br J Dermatol. 2016 May 28. doi: 10.1111/bjd.14722.
  11. ^ Kossard S. Postmenopausal frontal fibrosing alopecia: scarring alopecia in a pattern distribution. Arch Dermatol 1994;130:770-4.
  12. ^ Dhurat R, Saraogi P. Hair evaluation methods: merits and demerits. Int J Trichology. 2009;1(2):108-19.
  13. ^ Herskovitz I, Tosti A. Female pattern hair loss. Int J Endocrinol Metab. 2013;11(4):e9860.
  14. ^ Vañó-galván S, Molina-ruiz AM, Serrano-falcón C, et al. Frontal fibrosing alopecia: a multicenter review of 355 patients. J Am Acad Dermatol. 2014;70(4):670-8.
  15. ^ Pirmez R, Duque-Estrada B, Barreto T, Quintella DC, Cuzzi T. Successful Treatment of Facial Papules in Frontal Fibrosing Alopecia with Oral Isotretinoin. Skin Appendage Disord 2017;3:111-113. doi=10.1159/000464334

External links

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