Fungal folliculitis
Majocchi's granuloma | |
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Specialty | Dermatology |
Majocchi's granuloma is a skin condition characterized by deep, pustular plaques, and is a form of
Symptoms and signs
Majocchi's granuloma often presents as pink scaly patches with pustules at the periphery. It is most common on skin exposed to mechanical abuse—wear and tear—such as the upper and lower extremities. Patients experience papules, pustules, or even plaques and nodules at the infection site.[3] The white to red papules and pustules often have a perifollicular location. Hair shafts can be easily removed from the pustules and papules.[3] Itching is common.
Firm or fluctuant subcutaneous nodules or abscesses represent a second form of MG that is generally observed in immunosuppressed hosts. Nodules may develop in any hair-bearing part of the body, but are most often observed on the forearms, hands, and legs of infected individuals. Involvement of the scalp and face is rarely observed. Lesions start as solitary or multiple well-circumscribed perifollicular papulopustules and nodules with or without background erythema and scaling. In rare circumstances, the lesions may have keloidal features.[4]
Causes
Majocchi's granuloma is caused by a common group of fungi called dermatophytes. Unlike traditional
Mechanisms
Historically, many types of dermatophytes were known to cause the condition.
- small, perifollicular papular form, which is a localized dermal infection that usually occurs in healthy individuals
- deep subcutaneous plaque/nodular lesion form that occurs in immunosuppressed hosts. Tinea corporis is the name of the subset of this disease that remains restricted to the stratum corneum. Otherwise, the atypical deeper involvement is known as Majocchi's granuloma.[7] Because keratinophilic dermatophytes digest keratin, the introduction of keratin into the dermis may also act as a medium for continued growth of the organism.
Diagnosis
Primary diagnosis starts with a thorough physical exam and evaluation of medical history. Often, the condition is readily apparent to a medical practitioner and no further testing is required. If not readily apparent, a
This disease commonly affects both
Treatment
Oral
Research
The review article, "Majocchi’s granuloma: a symptom complex caused by fungal pathogens"[8] concludes that the Tzanck smear method is a rapid and easy diagnostic test. In addition, histopathologic examinations reveal granulomatous folliculitis in patients with MG. It found that systemic antifungals given at an adequate dose and for an appropriate duration are the drugs of choice; in general, topical antifungals alone do not clear the fungal infections.[4]
In "Majocchi's granumloma - Case report",[7] the authors discuss the case of a three-year-old child who presented with lesions around her jaw. It was reported that she had been using a combination of topical corticoids, anti-fungals and antibiotics during this period. The use of these products was ineffective. Drugs were suspended after 15 days of use and followed by cutaneous biopsy and histopathological examination. Mycological examination showed the presence of hyphae and spores compatible with MG. The patient was treated with griseofulvin for 8 weeks and went into remission.[citation needed]
The article "Tinea Corporis Gladiatorum Presenting as a Majocchi Granuloma"[9] discussed the importance of differential diagnosis. It includes a case report involving a 20-year-old male H who had been a part of schools wrestling team for the past six years. H presented with a 4-year history of follicular papules and pustules on his right forearm. This lesion had the typical clinical appearance. A skin biopsy showed an acute deep folliculitis compatible with a Majocchi granuloma, but fungal stainings with a Grocott stain was negative. This was the first reported case that showed that tinea corporis gladiatorum can present as a Majocchi granuloma. Thus, dermatologists must consider a Majocchi granuloma in the differential diagnosis of persistent skin lesions in wrestlers.
See also
- Domenico Majocchi
- List of cutaneous conditions
References
- ISBN 978-0723435716.
- ^ a b c "Majocchi Granuloma: Background, Pathophysiology, Epidemiology". 2017-07-14.
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(help) - ^ a b "Majocchi's Granuloma (Granuloma trichophyticum)". www.mdedge.com. Retrieved 2017-12-11.
- ^ PMID 22435879.
- ^ a b "Majocchi Granuloma: Background, Pathophysiology, Epidemiology". 2017-11-17.
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(help) - PMID 25405039.
- ^ PMID 25830999.
- PMID 22435879.
- PMID 22363858.