GC376

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GC376
Legal status
Legal status
  • US: Investigational drug
Identifiers
  • sodium (2S)-1-hydroxy-2-[[(2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoyl]amino]-3-(2-oxopyrrolidin-3-yl)propane-1-sulfonate
JSmol)
  • CC(C)C[C@@H](C(=O)N[C@@H](CC1CCNC1=O)C(O)S(=O)(=O)[O-])NC(=O)OCC2=CC=CC=C2.[Na+]
  • InChI=1S/C21H31N3O8S.Na/c1-13(2)10-16(24-21(28)32-12-14-6-4-3-5-7-14)19(26)23-17(20(27)33(29,30)31)11-15-8-9-22-18(15)25;/h3-7,13,15-17,20,27H,8-12H2,1-2H3,(H,22,25)(H,23,26)(H,24,28)(H,29,30,31);/q;+1/p-1/t15?,16-,17-,20?;/m0./s1
  • Key:BSPJDKCMFIPBAW-JPBGFCRCSA-M

GC376 is a broad-spectrum antiviral medication under development by the biopharmaceutical company Anivive Lifesciences for therapeutic uses in humans and animals.[1] Anivive licensed the exclusive worldwide patent rights to GC376 from Kansas State University.[2] As of 2020, GC376 is being investigated as treatment for COVID-19.[3] GC376 shows activity against many human and animal viruses including coronavirus and norovirus;[4] the most extensive research has been multiple in vivo studies in cats treating a coronavirus which causes deadly feline infectious peritonitis.[5] Other research supports use in porcine epidemic diarrhea virus.[6]

COVID-19

Crystal structure of the PEDV 3CLpro in complex with GC376.[6]

Since GC376 shows broad-spectrum activity against coronavirus,

SARS-CoV-2 (the coronavirus which causes COVID-19).[9] Another group of virologists at the University of Alberta led by D. Lorne Tyrrell
then released a separate publication confirming GC376's activity against 3CLpro in SARS-CoV-2 and also indicating GC376 had a potent antiviral effect.

Pharmacology

Pharmacodynamics

GC376 is a

polyprotein from maturing into its functional parts. Chemically, GC376 is the bisulfite adduct of an aldehyde GC373 and it behaves as a prodrug for that compound. This aldehyde forms a covalent bond with the cysteine-144 residue at the protease's active site, giving a monothioacetal and blocking the enzyme's normal function.[6][10]

See also

References

  1. ^ "Anivive". www.anivive.com. Retrieved 2020-05-14.
  2. ^ "Anivive licenses antiviral drug for fatal cat disease". www.k-state.edu. September 20, 2018. Retrieved 2020-05-14.
  3. ^ Stockwell B (6 May 2020). "COVID-19 Virtual Symposium". Retrieved 2020-05-14 – via YouTube.
  4. PMID 24055466
    .
  5. PMID 28901812
    .
  6. ^
    PMID 32098094
    .
  7. PMID 32006468
    .
  8. PMID 32022370
    .
  9. S2CID 216145410
    .
  10. S2CID 218551888
    .

External links
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