GLIS2
| GLIS family zinc finger 2 | |||||||
|---|---|---|---|---|---|---|---|
| Identifiers | |||||||
| Symbol | GLIS2 | ||||||
| Alt. symbols | NPHP7 | ||||||
Chr. 16 p13.3 | |||||||
| |||||||
GLIS family zinc finger 2 also known as GLIS2 is a human gene.[1][2]
Function
The
Glis2
knockout mice display decreased size and weight. The kidneys in these mice show progressive kidney atrophy and display symptoms similar to human nephronophthisis. Glis2 plays an essential role in the maintenance of renal tissue through prevention of apoptosis and fibrosis.[3]
Clinical significance
Mutations in the GLIS2 gene are associated with nephronophthisis.[3]
References
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