Genetically modified crops

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"GM Crops" redirects here. For the journal formerly printed under that name, see GM Crops & Food.

Part of a series on
Genetic engineering
 
Genetically modified organisms
History and regulation
Process
Applications
Controversies

Genetically modified crops (GM crops) are plants used in

biofuels, and other industrially useful goods, as well as for bioremediation.[1]

Farmers have widely adopted GM technology. Acreage increased from 1.7 million hectares in 1996 to 185.1 million hectares in 2016, some 12% of global cropland. As of 2016, major crop (

canola and cotton) traits consist of herbicide tolerance (95.9 million hectares) insect resistance (25.2 million hectares), or both (58.5 million hectares). In 2015, 53.6 million ha of Genetically modified maize were under cultivation (almost 1/3 of the maize crop). GM maize outperformed its predecessors: yield was 5.6 to 24.5% higher with less mycotoxins (−28.8%), fumonisin (−30.6%) and thricotecens (−36.5%). Non-target organisms were unaffected, except for lower populations some parasitoid wasps due to decreased populations of their pest host European corn borer; European corn borer is a target of Lepidoptera active Bt maize. Biogeochemical parameters such as lignin content did not vary, while biomass decomposition was higher.[2]

A 2014 meta-analysis concluded that GM technology adoption had reduced chemical

developed countries.[3] Pesticide poisonings were reduced by 2.4 to 9 million cases per year in India alone.[6] A 2011 review of the relationship between Bt cotton adoption and farmer suicides in India found that "Available data show no evidence of a 'resurgence' of farmer suicides" and that "Bt cotton technology has been very effective overall in India."[7] During the time period of Bt cotton introduction in India, farmer suicides instead declined by 25%.[6]

There is a scientific consensus[8][9][10][11] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[12][13][14][15][16] but that each GM food needs to be tested on a case-by-case basis before introduction.[17][18][19] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[20][21][22][23] The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[24][25][26][27]

However, opponents have objected to GM crops on grounds including environmental impacts, food safety, whether GM crops are needed to address food needs, whether they are sufficiently accessible to farmers in developing countries[28] and concerns over subjecting crops to intellectual property law. Safety concerns led 38 countries, including 19 in Europe, to officially prohibit their cultivation.[2]

History

Main article: History of genetic engineering

Humans have directly influenced the genetic makeup of plants to increase their value as a crop through

chick peas and flax) had all appeared by about 7,000 BC.[31] Traditional crop breeders have long introduced foreign germplasm into crops by creating novel crosses. A hybrid cereal grain was created in 1875, by crossing wheat and rye.[32] Since then traits including dwarfing genes and rust resistance have been introduced in that manner.[33] Plant tissue culture and deliberate mutations have enabled humans to alter the makeup of plant genomes.[34][35]

Modern advances in genetics have allowed humans to more directly alter plants genetics. In 1970

chloroplasts back into a plant cell that had its cell wall removed. With the introduction of the gene gun in 1987 it became possible to integrate foreign genes into a chloroplast.[44] Genetic transformation has become very efficient in some model organisms. In 2008 genetically modified seeds were produced in Arabidopsis thaliana by dipping the flowers in an Agrobacterium solution.[45] In 2013 CRISPR was first used to target modification of plant genomes.[46]

The first genetically engineered crop plant was tobacco, reported in 1983.

Environmental Protection Agency, after having been approved by the FDA, making it the first pesticide producing crop to be approved in the US.[54] In 1996 a total of 35 approvals had been granted to commercially grow 8 transgenic crops and one flower crop (carnation), with 8 different traits in 6 countries plus the EU.[49] By 2010, 29 countries had planted commercialised genetically modified crops and a further 31 countries had granted regulatory approval for transgenic crops to be imported.[55]

The first genetically modified animal to be commercialised was the

ultraviolet light.[56] The first genetically modified animal to be approved for food use was AquAdvantage salmon in 2015.[57] The salmon were transformed with a growth hormone-regulating gene from a Pacific Chinook salmon and a promoter from an ocean pout enabling it to grow year-round instead of only during spring and summer.[58]

GM banana cultivar QCAV-4 was approved by Australia and New Zealand in 2024. The banana resists the fungus that is fatal to the Cavendish banana, the dominant cultivar.[59]

Methods

Main article: Genetic engineering techniques
Plants (Solanum chacoense) being transformed using agrobacterium

Genetically engineered crops have genes added or removed using genetic engineering techniques,[60] originally including gene guns, electroporation, microinjection and agrobacterium. More recently, CRISPR and TALEN offered much more precise and convenient editing techniques.

Gene guns (also known as biolistics) "shoot" (direct high energy particles or radiations against

monocots like wheat or maize, for which transformation using Agrobacterium tumefaciens has been less successful.[62]
The major disadvantage of this procedure is that serious damage can be done to the cellular tissue.

vector, enabling transportation of foreign genes into plants. This method works especially well for dicotyledonous
plants like potatoes, tomatoes, and tobacco. Agrobacteria infection is less successful in crops like wheat and maize.

Electroporation is used when the plant tissue does not contain cell walls. In this technique, "DNA enters the plant cells through miniature pores which are temporarily caused by electric pulses."

Microinjection is used to directly inject foreign DNA into cells.[64]

Plant scientists, backed by results of modern comprehensive profiling of crop composition, point out that crops modified using GM techniques are less likely to have unintended changes than are conventionally bred crops.[65][66]

In research tobacco and Arabidopsis thaliana are the most frequently modified plants, due to well-developed transformation methods, easy propagation and well studied genomes.[67][68] They serve as model organisms for other plant species.

Introducing new genes into plants requires a

codons of the gene must be optimized for the organism due to codon usage bias
.

Types of modifications

Transgenic maize
containing a gene from the bacteria Bacillus thuringiensis

Transgenic

antigens for vaccinations.[70] A study led by the European Food Safety Authority (EFSA) also found viral genes in transgenic plants.[71]

Transgenic carrots have been used to produce the drug

rubisco enzyme (i.e. changing C3 plants into C4 plants[74]), by placing the rubisco in a carboxysome, by adding CO2 pumps in the cell wall,[75] or by changing the leaf form or size.[76][77][78][79] Plants have been engineered to exhibit bioluminescence that may become a sustainable alternative to electric lighting.[80]

Cisgenic

potatoes), and that plants in the cisgenic category should not require the same regulatory scrutiny as transgenics.[81]

Subgenic

Genetically modified plants can also be developed using

DuPont Pioneer to make a new variety of corn.[85]

Multiple trait integration

With multiple trait integration, several new traits may be integrated into a new crop.[86]

Economics

GM food's economic value to farmers is one of its major benefits, including in developing nations.[87][88][89] A 2010 study found that Bt corn provided economic benefits of $6.9 billion over the previous 14 years in five Midwestern states. The majority ($4.3 billion) accrued to farmers producing non-Bt corn. This was attributed to European corn borer populations reduced by exposure to Bt corn, leaving fewer to attack conventional corn nearby.[90][91] Agriculture economists calculated that "world surplus [increased by] $240.3 million for 1996. Of this total, the largest share (59%) went to U.S. farmers. Seed company Monsanto received the next largest share (21%), followed by US consumers (9%), the rest of the world (6%), and the germplasm supplier, Delta & Pine Land Company of Mississippi (5%)."[92]

According to the International Service for the Acquisition of Agri-biotech Applications (ISAAA), in 2014 approximately 18 million farmers grew biotech crops in 28 countries; about 94% of the farmers were resource-poor in developing countries. 53% of the global biotech crop area of 181.5 million hectares was grown in 20 developing countries.[93] PG Economics comprehensive 2012 study concluded that GM crops increased farm incomes worldwide by $14 billion in 2010, with over half this total going to farmers in developing countries.[94]

Forgoing these benefits is costly.

GM cowpea in west Africa, and GM maize/corn in Kenya.[95] They estimate Nigeria alone loses $33–46m annually.[95] The potential and alleged harms of GM crops must then be compared to these costs of delay.[95][96]

Critics challenged the claimed benefits to farmers over the prevalence of biased observers and by the absence of randomized controlled trials.[citation needed] The main Bt crop grown by small farmers in developing countries is cotton. A 2006 review of Bt cotton findings by agricultural economists concluded, "the overall balance sheet, though promising, is mixed. Economic returns are highly variable over years, farm type, and geographical location".[97]

In 2013 the European Academies Science Advisory Council (EASAC) asked the EU to allow the development of agricultural GM technologies to enable more sustainable agriculture, by employing fewer land, water, and nutrient resources. EASAC also criticizes the EU's "time-consuming and expensive regulatory framework" and said that the EU had fallen behind in the adoption of GM technologies.[98]

Participants in agriculture business markets include seed companies, agrochemical companies, distributors, farmers, grain elevators and universities that develop new crops/traits and whose agricultural extensions advise farmers on best practices.[citation needed] According to a 2012 review based on data from the late 1990s and early 2000s, much of the GM crop grown each year is used for livestock feed and increased demand for meat leads to increased demand for GM feed crops.[99] Feed grain usage as a percentage of total crop production is 70% for corn and more than 90% of oil seed meals such as soybeans. About 65 million metric tons of GM corn grains and about 70 million metric tons of soybean meals derived from GM soybean become feed.[99]

In 2014 the global value of biotech seed was US$15.7 billion; US$11.3 billion (72%) was in industrial countries and US$4.4 billion (28%) was in the developing countries.

Pioneer subsidiary, was the next biggest company in that market.[100] As of 2009, the overall Roundup line of products including the GM seeds represented about 50% of Monsanto's business.[101]

Some patents on GM traits have expired, allowing the legal development of generic strains that include these traits. For example, generic glyphosate-tolerant GM soybean is now available. Another impact is that traits developed by one vendor can be added to another vendor's proprietary strains, potentially increasing product choice and competition.

DuPont Pioneer.[108]

Yield

In 2014, the largest review yet concluded that GM crops' effects on farming were positive. The meta-analysis considered all published English-language examinations of the agronomic and economic impacts between 1995 and March 2014 for three major GM crops: soybean, maize, and cotton. The study found that herbicide-tolerant crops have lower production costs, while for insect-resistant crops the reduced pesticide use was offset by higher seed prices, leaving overall production costs about the same.[3][109]

Yields increased 9% for herbicide tolerance and 25% for insect resistant varieties. Farmers who adopted GM crops made 69% higher profits than those who did not. The review found that GM crops help farmers in developing countries, increasing yields by 14 percentage points.[109]

The researchers considered some studies that were not peer-reviewed and a few that did not report sample sizes. They attempted to correct for

academic journals. The large data set allowed the study to control for potentially confounding variables such as fertilizer use. Separately, they concluded that the funding source did not influence study results.[109]

Under special conditions meant to reveal only genetic yield factors, many GM crops are known to actually have lower yields. This is variously due to one or both of: Yield drag, wherein the trait itself lowers yield, either by competing for synthesis

pest pressure which is often the point of the GM trait.[110] See for example Roundup Ready § Productivity claims
.

Gene editing may also increase yields non-specific to the use of any biocides/pesticides. In March 2022, field test results showed CRISPR-based gene knockout of KRN2 in maize and OsKRN2 in rice increased grain yields by ~10% and ~8% without any detected negative effects.[111][112]

Traits

Genetically modified King Edward potato (right) next to King Edward which has not been genetically modified (left). Research field belonging to the Swedish University of Agricultural Sciences in 2019.

GM crops grown today, or under development, have been modified with various

pest resistance, production of useful goods such as biofuel or drugs, and ability to absorb toxins and for use in bioremediation
of pollution.

Recently,

brinjal (eggplant).[114]

Extended shelf life

The first genetically modified crop approved for sale in the U.S. was the

FlavrSavr tomato, which had a longer shelf life.[52] First sold in 1994, FlavrSavr tomato production ceased in 1997.[115]
It is no longer on the market.

In November 2014, the USDA approved a

GM potato that prevents bruising.[116][117]

In February 2015

kanamycin. The genetic engineering involved cultivation in the presence of kanamycin, which allowed only resistant cultivars to survive. Humans consuming apples do not acquire kanamycin resistance, per arcticapple.com.[121] The FDA approved the apples in March 2015.[122]

Improved photosynthesis

Plants use non-photochemical quenching to protect them from excessive amounts of sunlight. Plants can switch on the quenching mechanism almost instantaneously, but it takes much longer for it to switch off again. During the time that it is switched off, the amount of energy that is wasted increases.[123] A genetic modification in three genes allows to correct this (in a trial with tobacco plants). As a result, yields were 14-20% higher, in terms of the weight of the dry leaves harvested. The plants had larger leaves, were taller and had more vigorous roots.[123][124]

Another improvement that can be made on the photosynthesis process (with

cereal crops, such as rice.[125][126][127][128][129]

Improved biosequestration capability

The

Harnessing Plants Initiative
focuses on creating GM plants that have increased root mass, root depth and suberin content.

Improved nutritional value

Edible oils

Some GM soybeans offer improved oil profiles for processing.

fish oils.[131][132]

Vitamin enrichment

Golden rice, developed by the International Rice Research Institute (IRRI), provides greater amounts of vitamin A targeted at reducing vitamin A deficiency.[133][134] As of January 2016, golden rice has not yet been grown commercially in any country.[135]

Toxin reduction

A genetically modified

glucosides and enhanced protein and other nutrients (called BioCassava).[136]

In November 2014, the USDA approved a potato that prevents bruising and produces less acrylamide when fried.[116][117] They do not employ genes from non-potato species. The trait was added to the Russet Burbank, Ranger Russet and Atlantic varieties.[116]

Stress resistance

Plants have been engineered to tolerate non-biological

stressors, such as drought,[116][117][137][138] frost,[139] and high soil salinity.[68] In 2011, Monsanto's DroughtGard maize became the first drought-resistant GM crop to receive US marketing approval.[140]

Drought resistance occurs by modifying the plant's genes responsible for the mechanism known as the crassulacean acid metabolism (CAM), which allows the plants to survive despite low water levels. This holds promise for water-heavy crops such as rice, wheat, soybeans and poplar to accelerate their adaptation to water-limited environments.[141][142] Several salinity tolerance mechanisms have been identified in salt-tolerant crops. For example, rice, canola and tomato crops have been genetically modified to increase their tolerance to salt stress.[143][144]

Herbicides

Glyphosate

The most prevalent GM trait is herbicide tolerance,

aromatic amino acids phenylalanine, tyrosine, and tryptophan. The shikimate pathway is not present in animals, which instead obtain aromatic amino acids from their diet. More specifically, glyphosate inhibits the enzyme 5-enolpyruvylshikimate-3-phosphate synthase
(EPSPS).

This trait was developed because the herbicides used on grain and grass crops at the time were highly toxic and not effective against narrow-leaved weeds. Thus, developing crops that could withstand spraying with glyphosate would both reduce environmental and health risks, and give an agricultural edge to the farmer.[147]

Some micro-organisms have a version of EPSPS that is resistant to glyphosate inhibition. One of these was isolated from an

soybeans
.

The

beta-glucuronidase (GUS) from Escherichia coli as a marker. The DNA was injected into the soybeans using the particle acceleration method. Soybean cultivar A54O3 was used for the transformation
.

Bromoxynil

Tobacco plants have been engineered to be resistant to the herbicide bromoxynil.[150]

Glufosinate

Crops have been commercialized that are resistant to the herbicide glufosinate, as well.[151] Crops engineered for resistance to multiple herbicides to allow farmers to use a mixed group of two, three, or four different chemicals are under development to combat growing herbicide resistance.[152][153]

2,4-D

In October 2014 the US EPA registered

2,4-D, in six states.[154][155][156] Inserting a bacterial aryloxyalkanoate dioxygenase gene, aad1 makes the corn resistant to 2,4-D.[154][157] The USDA had approved maize and soybeans with the mutation in September 2014.[158]

Dicamba

Monsanto has requested approval for a stacked strain that is tolerant of both glyphosate and

temperature inversions, and rain or high temperatures are in the next day forecast. However, these conditions typically only occur during June and July for a few hours at a time.[161][162]

Pest resistance

Insects

Tobacco, corn, rice and some other crops have been engineered to express genes encoding for insecticidal proteins from Bacillus thuringiensis (Bt).[163][164] The introduction of Bt crops during the period between 1996 and 2005 has been estimated to have reduced the total volume of insecticide active ingredient use in the United States by over 100 thousand tons. This represents a 19.4% reduction in insecticide use.[165]

In the late 1990s, a genetically modified potato that was resistant to the Colorado potato beetle was withdrawn because major buyers rejected it, fearing consumer opposition.[116]

Viruses

Papaya, potatoes, and squash have been engineered to resist viral pathogens such as cucumber mosaic virus which, despite its name, infects a wide variety of plants.[166] Virus resistant papaya were developed in response to a papaya ringspot virus (PRV) outbreak in Hawaii in the late 1990s. They incorporate PRV DNA.[167][168] By 2010, 80% of Hawaiian papaya plants were genetically modified.[169][170]

Potatoes were engineered for resistance to

potato leaf roll virus and Potato virus Y in 1998. Poor sales led to their market withdrawal after three years.[171]

Yellow squash that were resistant to at first two, then three viruses were developed, beginning in the 1990s. The viruses are watermelon, cucumber and zucchini/courgette yellow mosaic. Squash was the second GM crop to be approved by US regulators. The trait was later added to zucchini.[172]

Many strains of corn have been developed in recent years to combat the spread of Maize dwarf mosaic virus, a costly virus that causes stunted growth which is carried in Johnson grass and spread by aphid insect vectors. These strands are commercially available although the resistance is not standard among GM corn variants.[173]

By-products

Drugs

In 2012, the FDA approved the first

Gaucher's Disease.[174] Tobacco plants have been modified to produce therapeutic antibodies.[175]

Biofuel

bio-ethanol because lignin limits the accessibility of cellulose microfibrils to depolymerization by enzymes.[180] Besides with trees, the chemically labile lignin bonds are also very useful for cereal crops such as maize,[181][182]

Materials

Companies and labs are working on plants that can be used to make

Oilseed can be modified to produce fatty acids for detergents, substitute fuels and petrochemicals
.

Non-pesticide pest management products

Besides the modified oilcrop above,

Spodoptera frugiperda version. The H. armigera pheromones have been tested and are effective.[185]

Bioremediation

Scientists at the University of York developed a weed (

TNT and RDX-explosive soil contaminants in 2011.[186] 16 million hectares in the US (1.5% of the total surface) are estimated to be contaminated with TNT and RDX. However A. thaliana was not tough enough for use on military test grounds.[187] Modifications in 2016 included switchgrass and bentgrass.[188]

Genetically modified plants have been used for bioremediation of contaminated soils. Mercury, selenium and organic pollutants such as polychlorinated biphenyls (PCBs).[187][189]

Marine environments are especially vulnerable since pollution such as

oil spills are not containable. In addition to anthropogenic pollution, millions of tons of petroleum annually enter the marine environment from natural seepages. Despite its toxicity, a considerable fraction of petroleum oil entering marine systems is eliminated by the hydrocarbon-degrading activities of microbial communities. Particularly successful is a recently discovered group of specialists, the so-called hydrocarbonoclastic bacteria (HCCB) that may offer useful genes.[190]

Asexual reproduction

Crops such as

inbred varieties and crosses them into a hybrid strain that is then sold. Related plants like sorghum and gamma grass are able to perform apomixis, a form of asexual reproduction that keeps the plant's DNA intact. This trait is apparently controlled by a single dominant gene, but traditional breeding has been unsuccessful in creating asexually-reproducing maize. Genetic engineering offers another route to this goal. Successful modification would allow farmers to replant harvested seeds that retain desirable traits, rather than relying on purchased seed.[191]

Other

Genetic modifications to some crops also exist, which make it easier to process the crop, i.e. by growing it in a more compact form.

marine algae, which uses it to gain energy from the blue light that is able to penetrate seawater more effectively than longer wavelengths.[194][195]

Crops

See also: List of genetically modified crops

Herbicide tolerance

Crop Use Countries approved in First approved[196] Notes
Alfalfa Animal feed[197] US 2005 Approval withdrawn in 2007[198] and then re-approved in 2011[199]
Canola Cooking oil

Margarine

Emulsifiers in packaged foods[197]

Australia 2003
Canada 1995
US 1995
Cotton
 Fiber
Cottonseed oil
Animal feed[197] 		Argentina 2001
Australia 2002
Brazil 2008
Colombia 2004
Costa Rica 2008
Mexico 2000
Paraguay 2013
South Africa 2000
US 1994
Maize Animal feed

high-fructose corn syrup

corn starch[197]

Argentina 1998
Brazil 2007
Canada 1996
Colombia 2007
Cuba 2011
European Union 1998 Grown in Portugal, Spain, Czech Republic, Slovakia and Romania[200]
Honduras 2001
Paraguay 2012
Philippines 2002
South Africa 2002
US 1995
Uruguay 2003
Soybean Animal feed

Soybean oil[197]

Argentina 1996
Bolivia 2005
Brazil 1998
Canada 1995
Chile 2007
Costa Rica 2001
Mexico 1996
Paraguay 2004
South Africa 2001
US 1993
Uruguay 1996
Sugar Beet Food[201] Canada 2001
US 1998 Commercialised 2007,[202] production blocked 2010, resumed 2011.[201]

Insect resistance

Crop Use Countries approved in First approved[196] Notes
Cotton
 Fiber
Cottonseed oil
Animal feed[197] 		Argentina 1998
Australia 2003
Brazil 2005
Burkina Faso 2009
China 1997
Colombia 2003
Costa Rica 2008
India 2002 Largest producer of Bt cotton[203]
Mexico 1996
Myanmar 2006[N 1]
Pakistan 2010[N 1]
Paraguay 2007
South Africa 1997
Sudan 2012
US 1995
Eggplant
 Food Bangladesh 2013 12 ha planted on 120 farms in 2014[204]
Maize Animal feed

high-fructose corn syrup

corn starch[197]

Argentina 1998
Brazil 2005
Colombia 2003
Mexico 1996 Centre of origin for maize[205]
Paraguay 2007
Philippines 2002
South Africa 1997
Uruguay 2003
US 1995
Poplar Tree China 1998 543 ha of bt poplar planted in 2014[206]

Other modified traits

Crop Use Trait Countries approved in First approved[196] Notes
Canola Cooking oil

Margarine

Emulsifiers in packaged foods[197]

High
laurate
canola 		Canada 1996
US 1994
Phytase production US 1998
Carnation Ornamental Delayed senescence Australia 1995
Norway 1998
Modified flower colour Australia 1995
Colombia 2000 In 2014 4 ha were grown in greenhouses for export[207]
European Union 1998 Two events expired 2008, another approved 2007
Japan 2004
Malaysia 2012 For ornamental purposes
Norway 1997
Maize Animal feed

high-fructose corn syrup

corn starch[197]

Increased lysine Canada 2006
US 2006
Drought tolerance Canada 2010
US 2011
Papaya Food[197] Virus resistance China 2006
US 1996 Mostly grown in Hawaii[197]
Petunia Ornamental Modified flower colour China 1997[208]
Potato Food[197] Virus resistance Canada 1999
US 1997
Industrial[209] Modified starch US 2014
Rose Ornamental Modified flower colour Australia 2009 Surrendered renewal
Colombia 2010[N 2] Greenhouse cultivation for export only.
Japan 2008
US 2011
Soybean Animal feed

Soybean oil[197]

Increased oleic acid production Argentina 2015
Canada 2000
US 1997
Stearidonic acid production Canada 2011
US 2011
Squash Food[197] Virus resistance US 1994
Sugar Cane Food Drought tolerance Indonesia 2013 Environmental certificate only
Tobacco Cigarettes Nicotine reduction US 2002

GM Camelina

Several modifications of Camelina sativa have been done, see §Edible oils and §Non-pesticide pest management products above.

Development

The number of USDA-approved field releases for testing grew from 4 in 1985 to 1,194 in 2002 and averaged around 800 per year thereafter. The number of sites per release and the number of gene constructs (ways that the gene of interest is packaged together with other elements) – have rapidly increased since 2005. Releases with agronomic properties (such as drought resistance) jumped from 1,043 in 2005 to 5,190 in 2013. As of September 2013, about 7,800 releases had been approved for corn, more than 2,200 for soybeans, more than 1,100 for cotton, and about 900 for potatoes. Releases were approved for herbicide tolerance (6,772 releases), insect resistance (4,809), product quality such as flavor or nutrition (4,896), agronomic properties like drought resistance (5,190), and virus/fungal resistance (2,616). The institutions with the most authorized field releases include Monsanto with 6,782, Pioneer/DuPont with 1,405, Syngenta with 565, and USDA's Agricultural Research Service with 370. As of September 2013 USDA had received proposals for releasing GM rice, squash, plum, rose, tobacco, flax, and chicory.[210]

Farming practices

Resistance

Bacillus thuringiensis

Constant exposure to a toxin creates evolutionary pressure for pests resistant to that toxin.[211] Over-reliance on glyphosate and a reduction in the diversity of weed management practices allowed the spread of glyphosate resistance in 14 weed species in the US,[210] and in soybeans.[5]

To reduce resistance to Bacillus thuringiensis (Bt) crops, the 1996 commercialization of transgenic cotton and maize came with a management strategy to prevent insects from becoming resistant. Insect resistance management plans are mandatory for Bt crops. The aim is to encourage a large population of pests so that any (recessive) resistance genes are diluted within the population. Resistance lowers evolutionary fitness in the absence of the stressor, Bt. In refuges, non-resistant strains outcompete resistant ones.[212]

With sufficiently high levels of transgene expression, nearly all of the heterozygotes (S/s), i.e., the largest segment of the pest population carrying a resistance allele, will be killed before maturation, thus preventing transmission of the resistance gene to their progeny.[213] Refuges (i. e., fields of nontransgenic plants) adjacent to transgenic fields increases the likelihood that homozygous resistant (s/s) individuals and any surviving heterozygotes will mate with susceptible (S/S) individuals from the refuge, instead of with other individuals carrying the resistance allele. As a result, the resistance gene frequency in the population remains lower.

Complicating factors can affect the success of the high-dose/refuge strategy. For example, if the temperature is not ideal, thermal stress can lower Bt toxin production and leave the plant more susceptible. More importantly, reduced late-season expression has been documented, possibly resulting from

promoter.[214] The success of the high-dose/refuge strategy has successfully maintained the value of Bt crops. This success has depended on factors independent of management strategy, including low initial resistance allele frequencies, fitness costs associated with resistance, and the abundance of non-Bt host plants outside the refuges.[215]

Companies that produce Bt seed are introducing strains with multiple Bt proteins. Monsanto did this with Bt cotton in India, where the product was rapidly adopted.

lepidopteran corn pests, such as European corn borer. Increased concerns for resistance with seed mixtures include partially resistant larvae on a Bt plant being able to move to a susceptible plant to survive or cross pollination of refuge pollen on to Bt plants that can lower the amount of Bt expressed in kernels for ear feeding insects.[218][219]

Herbicide resistance

Palmer amaranth is a weed that competes with cotton. A native of the southwestern US, it traveled east and was first found resistant to glyphosate in 2006, less than 10 years after GM cotton was introduced.[220][221]

Plant protection

Farmers generally use less insecticide when they plant Bt-resistant crops. Insecticide use on corn farms declined from 0.21 pound per planted acre in 1995 to 0.02 pound in 2010. This is consistent with the decline in European corn borer populations as a direct result of Bt corn and cotton. The establishment of minimum refuge requirements helped delay the evolution of Bt resistance. However, resistance appears to be developing to some Bt traits in some areas.[210] In Columbia, GM cotton has reduced insecticide usage by 25% and herbicide usage by 5%, and GM corn has reduced insecticide and herbicide usage by 66% and 13%, respectively.[222]

Tillage

By leaving at least 30% of crop residue on the soil surface from harvest through planting,

conservation tillage reduces soil erosion from wind and water, increases water retention, and reduces soil degradation as well as water and chemical runoff. In addition, conservation tillage reduces the carbon footprint of agriculture.[223] A 2014 review covering 12 states from 1996 to 2006, found that a 1% increase in herbicde-tolerant (HT) soybean adoption leads to a 0.21% increase in conservation tillage and a 0.3% decrease in quality-adjusted herbicide use.[223]

Greenhouse gas emissions

Combined features of increased yield, decreased land use, reduced use of fertilizer and reduced farming machinery use create a feedback loop that reduces carbon emissions related to farming. These reductions have been estimated at 7.5% of total agricultural emissions in the EU or 33 millions tons of CO2[224] and an estimated 8.76 million tons of CO2 in Columbia.[222]

Drought tolerance

The use of drought tolerant crops can increase yield in water-scarce locations, making farming possible in new areas. The adoption of drought tolerant maize in Ghana was shown to increase yield by more than 150% and boost commercialization intensity, although it did not significantly affect farm income.[225]

Regulation

Main articles:
Regulation of the release of genetic modified organisms

The regulation of genetic engineering concerns the approaches taken by governments to assess and manage the risks associated with the development and release of genetically modified crops. There are differences in the regulation of GM crops between countries, with some of the most marked differences occurring between the US and Europe. Regulation varies in a given country depending on the intended use of each product. For example, a crop not intended for food use is generally not reviewed by authorities responsible for food safety.[226][227]

Production

GM crops production in the World (ISAAA Brief 2019)
  More than 10 million hectares
  Between 50,000 and 10 million hectares
  Less than 50,000 hectares
  No biotech crops

In 2013, GM crops were planted in 27 countries; 19 were developing countries and 8 were developed countries. 2013 was the second year in which developing countries grew a majority (54%) of the total GM harvest. 18 million farmers grew GM crops; around 90% were small-holding farmers in developing countries.[1]

Country 2013– GM planted area (million hectares)[228] Biotech crops
US 70.1 Maize, Soybean, Cotton, Canola, Sugarbeet, Alfalfa, Papaya, Squash
Brazil 40.3 Soybean, Maize, Cotton
Argentina 24.4 Soybean, Maize, Cotton
India 11.0 Cotton
Canada 10.8 Canola, Maize, Soybean, Sugarbeet
Total 175.2 ----

The United States Department of Agriculture (USDA) reports every year on the total area of GM crop varieties planted in the United States.[229][230] According to National Agricultural Statistics Service, the states published in these tables represent 81–86 percent of all corn planted area, 88–90 percent of all soybean planted area, and 81–93 percent of all upland cotton planted area (depending on the year).

Global estimates are produced by the International Service for the Acquisition of Agri-biotech Applications (ISAAA) and can be found in their annual reports, "Global Status of Commercialized Transgenic Crops".[1][231]

Farmers have widely adopted GM technology (see figure). Between 1996 and 2013, the total surface area of land cultivated with GM crops increased by a factor of 100, from 17,000 square kilometers (4,200,000 acres) to 1,750,000 km2 (432 million acres).[1] 10% of the world's arable land was planted with GM crops in 2010.[55] As of 2011, 11 different transgenic crops were grown commercially on 395 million acres (160 million hectares) in 29 countries such as the US, Brazil, Argentina, India, Canada, China, Paraguay, Pakistan, South Africa, Uruguay, Bolivia, Australia, Philippines, Myanmar, Burkina Faso, Mexico and Spain.[55] One of the key reasons for this widespread adoption is the perceived economic benefit the technology brings to farmers. For example, the system of planting glyphosate-resistant seed and then applying glyphosate once plants emerged provided farmers with the opportunity to dramatically increase the yield from a given plot of land, since this allowed them to plant rows closer together. Without it, farmers had to plant rows far enough apart to control post-emergent weeds with mechanical tillage.[232] Likewise, using Bt seeds means that farmers do not have to purchase insecticides, and then invest time, fuel, and equipment in applying them. However critics have disputed whether yields are higher and whether chemical use is less, with GM crops. See Genetically modified food controversies article for information.

Land area used for genetically modified crops by country (1996–2009), in millions of hectares. In 2011, the land area used was 160 million hectares, or 1.6 million square kilometers.[55]

In the US, by 2014, 94% of the planted area of soybeans, 96% of cotton and 93% of corn were genetically modified varieties.[233][234][235] Genetically modified soybeans carried herbicide-tolerant traits only, but maize and cotton carried both herbicide tolerance and insect protection traits (the latter largely Bt protein).[236] These constitute "input-traits" that are aimed to financially benefit the producers, but may have indirect environmental benefits and cost benefits to consumers. The Grocery Manufacturers of America estimated in 2003 that 70–75% of all processed foods in the U.S. contained a GM ingredient.[237]

Europe grows relatively few genetically engineered crops[238] with the exception of Spain, where one fifth of maize is genetically engineered,[239] and smaller amounts in five other countries.[240] The EU had a 'de facto' ban on the approval of new GM crops, from 1999 until 2004.[241][242] GM crops are now regulated by the EU.[243] In 2015, genetically engineered crops are banned in 38 countries worldwide, 19 of them in Europe.[244][245] Developing countries grew 54 percent of genetically engineered crops in 2013.[1]

In recent years GM crops expanded rapidly in developing countries. In 2013 approximately 18 million farmers grew 54% of worldwide GM crops in developing countries.[1] 2013's largest increase was in Brazil (403,000 km2 versus 368,000 km2 in 2012). GM cotton began growing in India in 2002, reaching 110,000 km2 in 2013.[1]

According to the 2013 ISAAA brief: "a total of 36 countries (35 + EU-28) have granted regulatory approvals for biotech crops for food and/or feed use and for environmental release or planting since 1994 ... a total of 2,833 regulatory approvals involving 27 GM crops and 336 GM events (NB: an "event" is a specific genetic modification in a specific species) have been issued by authorities, of which 1,321 are for food use (direct use or processing), 918 for feed use (direct use or processing) and 599 for environmental release or planting. Japan has the largest number (198), followed by the U.S.A. (165, not including "stacked" events), Canada (146), Mexico (131), South Korea (103), Australia (93), New Zealand (83), European Union (71 including approvals that have expired or under renewal process), Philippines (68), Taiwan (65), Colombia (59), China (55) and South Africa (52). Maize has the largest number (130 events in 27 countries), followed by cotton (49 events in 22 countries), potato (31 events in 10 countries), canola (30 events in 12 countries) and soybean (27 events in 26 countries).[1]

Controversy

Main article: Genetically modified food controversies

Direct genetic engineering has been controversial since its introduction. Most, but not all of the controversies are over GM foods rather than crops per se. GM foods are the subject of protests, vandalism, referendums, legislation, court action[246] and scientific disputes. The controversies involve consumers, biotechnology companies, governmental regulators, non-governmental organizations and scientists.

Opponents have objected to GM crops on multiple grounds including environmental impacts, food safety, whether GM crops are needed to address food needs, whether they are sufficiently accessible to farmers in developing countries,[28] concerns over subjecting crops to intellectual property law, and on religious grounds.[247] Secondary issues include labeling, the behavior of government regulators, the effects of pesticide use and pesticide tolerance.

A significant environmental concern about using genetically modified crops is possible cross-breeding with related crops, giving them advantages over naturally occurring varieties. One example is a glyphosate-resistant rice crop that crossbreeds with a weedy relative, giving the weed a competitive advantage. The transgenic hybrid had higher rates of photosynthesis, more shoots and flowers, and more seeds than the non-transgenic hybrids.[248] This demonstrates the possibility of ecosystem damage by GM crop usage.

The role of biopiracy in the development of GM crops is also potentially problematic, as developed countries have gotten economic gain by using the genetic resources of developing countries. In the twentieth century, the International Rice Research Institute catalogued the genomes of almost 80,000 varieties of rice from Asian farms, which has since been used to create new higher yielding varieties of rice. These new varieties create almost 655 million dollars of economic gain for Australia, USA, Canada, and New Zealand every year.[249]

There is a scientific consensus[8][9][10][11] that currently available food derived from GM crops poses no greater risk to human health than conventional food,[12][13][14][15][16] but that each GM food needs to be tested on a case-by-case basis before introduction.[17][18][19] Nonetheless, members of the public are much less likely than scientists to perceive GM foods as safe.[20][21][22][23] The legal and regulatory status of GM foods varies by country, with some nations banning or restricting them, and others permitting them with widely differing degrees of regulation.[24][25][26][27]

No reports of ill effects from GM food have been documented in the human population.[250][251][252] GM crop labeling is required in many countries, although the United States Food and Drug Administration does not, nor does it distinguish between approved GM and non-GM foods.[253] The United States enacted a law that requires labeling regulations to be issued by July 2018. It allows indirect disclosure such as with a phone number, bar code, or web site.[254]

Advocacy groups such as Center for Food Safety, Union of Concerned Scientists, and Greenpeace claim that risks related to GM food have not been adequately examined and managed, that GM crops are not sufficiently tested and should be labelled, and that regulatory authorities and scientific bodies are too closely tied to industry. [citation needed] Some studies have claimed that genetically modified crops can cause harm;[255][256] a 2016 review that reanalyzed the data from six of these studies found that their statistical methodologies were flawed and did not demonstrate harm, and said that conclusions about GM crop safety should be drawn from "the totality of the evidence ... instead of far-fetched evidence from single studies".[257]

See also

Notes

  1. ^ a b No official public documentation available
  2. ^ No public documents

References

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    The literature about Biodiversity and the GE food/feed consumption has sometimes resulted in animated debate regarding the suitability of the experimental designs, the choice of the statistical methods or the public accessibility of data. Such debate, even if positive and part of the natural process of review by the scientific community, has frequently been distorted by the media and often used politically and inappropriately in anti-GE crops campaigns.
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    Despite various concerns, today, the American Association for the Advancement of Science, the World Health Organization, and many independent international science organizations agree that GMOs are just as safe as other foods. Compared with conventional breeding techniques, genetic engineering is far more precise and, in most cases, less likely to create an unexpected outcome.
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