GP1BA

Source: Wikipedia, the free encyclopedia.
GP1BA
Gene ontology
Molecular function
Cellular component
Biological process
Sources:Amigo / QuickGO
Ensembl
UniProt
RefSeq (mRNA)

NM_000173

NM_010326

RefSeq (protein)

NP_000164

NP_034456

Location (UCSC)Chr 17: 4.93 – 4.94 MbChr 11: 70.53 – 70.53 Mb
PubMed search[3][4]
Wikidata
View/Edit HumanView/Edit Mouse

Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of Differentiation 42b), is a protein that in humans is encoded by the GP1BA gene.

Function

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein receptor composed of a heterodimer, an alpha chain and a beta chain, that are linked by disulfide bonds.[5] The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V to form the glycoprotein Ib-IX-V complex. Binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury,[6] and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis.[7] This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard–Soulier syndromes and platelet-type von Willebrand disease.[8]

Interactions

GP1BA has been shown to interact with YWHAZ[9][10][11] and FLNB.[12]

See also

References

  1. ^ a b c GRCh38: Ensembl release 89: ENSG00000185245 - Ensembl, May 2017
  2. ^ a b c GRCm38: Ensembl release 89: ENSMUSG00000050675 - Ensembl, May 2017
  3. ^ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ^ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. PMID 3303030
    .
  6. . Retrieved 2023-09-08.
  7. .
  8. ^ "Entrez Gene: GP1BA glycoprotein Ib (platelet), alpha polypeptide".
  9. PMID 9454760
    .
  10. .
  11. .
  12. .

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This page is based on the copyrighted Wikipedia article: GP1BA. Articles is available under the CC BY-SA 3.0 license; additional terms may apply.Privacy Policy